摘要
目的探讨他克莫司联合308nm准分子激光在面部白癜风治疗中的应用效果。方法选取2017年2月-2019年2月医院84例面部白癜风患者为研究对象,根据入院单双号将受试者进行分组,其中对照组42例患者接受308nm准分子激光治疗,研究组42例患者在对照组的基础上联合他克莫司软膏治疗,比较两组患者治疗后1个月、3个月时的治疗总有效率以及治疗前后白斑面积与皮损区IL-17水平变化。结果研究组患者在治疗后1个月、3个月时的治疗总有效率均显著高于对照组(P<0.05),与治疗前相比,治疗后两组患者白斑面积及皮损区IL-17水平均显著减少,且研究组显著少于对照组(P<0.05)。结论他克莫司联合308nm准分子激光可有效缩小白斑面积,降低皮损区IL-17水平,疗效确切。
Objective To investigate the effects of tacrolimus plus 308nm excimer laser in the treatment of facial vitiligo. Methods From Feb.2017 to Feb.2019, 84 patients with facial vitiligo were selected and divided into two groups. 42 patients in control group were treated with 308 nm excimer laser and other 42 patients in research group were treated with tacrolimus ointment based on control group. The total effective rate, changes of leukoplakia area and IL-17 level in skin lesion area before and after treatment were compared between the two groups at 1 and 3 months after treatment. Results At 1 month and 3 months after treatment, the total effective rate of research group was significant higher than control group(P<0.05). Compared with before, the area of white patches and level of IL-17 in the skin lesion area of the two groups were significant decreased after treatment. The white patches and level of IL-17 in research group was significant lower than control group(P<0.05). Conclusion Tacrolimus plus 308nm excimer laser can reduce the area of white patches and the level of IL-17 effectively.
作者
裴宇
PEI Yu(Dermatology&STD Department,Jingzhou Dermatological Disease Prevention and Treatment Hospital,Jingzhou Hubei 434020,China)
出处
《中国继续医学教育》
2020年第13期131-133,共3页
China Continuing Medical Education
