摘要
利用视网膜功能测量仪对眼底进行结构成像来直接观察体内丰富的循环系统,并对视网膜的血氧饱和度及血管直径进行无创、定量的功能性成像测量。对糖尿病患者和健康人群进行视网膜功能成像并作定量比较分析,结果表明,在糖尿病患者中,视网膜动脉血氧饱和度相比健康人群有显著性提高,视网膜动静脉血氧饱和度差值有显著性增大,视网膜黄斑中心凹无灌注区面积也有显著增大。此外,在糖尿病患者和健康人群中,视网膜动静脉的直径均存在差异,且静脉直径总大于动脉直径。研究结果表明通过视网膜功能成像可以检测糖尿病患者的视网膜氧代谢和灌注率等参数的临床变化,帮助医生更好地观察、评估糖尿病患者视网膜微血管的病理改变,并在糖尿病患者眼科并发症的早期诊断和预后评估方面具有一定的应用潜力。
In this study,via the retinal functional imaging device,not only the structural information of the retina is imaged,but also the functional information such as the retinal oxygen saturation and vessel diameter is imaged and measured noninvasively and quantitatively.By comparing quantitatively the functional imaging results of diabetes patients and healthy controls,significantly elevated arterial oxygen saturation and arterial-venous oxygen saturation difference are found in diabetes patients.The area of the foveal avascular zone is also significantly increased in diabetes patients.The result also shows that there are significant differences between the average diameters of arteries and veins both in diabetes patients and healthy controls,and the arterial diameter is always larger than the venous diameter.The study demonstrates that by using the retinal functional imaging method,the clinical changes of retinal oxygen metabolism as well as the perfusion rate in diabetes patients can be detected,which helps doctors to better observe and evaluate the pathological changes of the retinal microvessels in diabetes patients.In addition,the retinal functional imaging technique has the application potential for the early diagnosis and prognostic evaluation of ophthalmic complications associated with diabetes.
作者
邹达
王珂欣
刘刚军
任秋实
卢闫晔
Zou Da;Wang Kexin;Liu Gangjun;Ren Qiushi;Lu Yanye(Department of Biomedical Engineering,College of Engineering,Peking University,Beijing 100871,China;Department of Ophthalmology,Peking University First Hospital,Beijing 100034,China;Institute of Biomedical Engineering,Peking University Shenzhen Graduate School,Shenzhen,Guangdong 518055,China;Shenzhen Bay Laboratory,Shenzhen,Guangdong 518052,China)
出处
《激光与光电子学进展》
CSCD
北大核心
2020年第5期194-201,共8页
Laser & Optoelectronics Progress
基金
国家自然科学基金(81421004)
国家重大科学仪器设备开发专项(2013YQ030651)。
关键词
医用光学
视网膜功能成像
血氧饱和度
血管直径
眼底成像
糖尿病
medical optics
retinal functional imaging
blood oxygen saturation
vessel diameter
fundus imaging
diabetes mellitus
