摘要
目的分析重庆医科大学附属永川医院收治的89例新型冠状病毒肺炎患者的临床特征。方法回顾性分析2020年1月22日至2020年2月17日重庆医科大学附属永川医院收治的89例新型冠状病毒肺炎患者的流行病学资料、临床症状及实验室检查结果。结果发热和咳嗽为COVID-19的主要症状,但仍有6例无症状携带者;重型组的淋巴细胞绝对值、淋巴细胞百分比、CD3^+细胞计数、CD4^+细胞计数、CD8^+细胞计数明显低于普通组,差异具有统计学意义(P<0.05)。重型组的C反应蛋白及IL-6水平明显高于普通组及轻症组,差异具有统计学意义(P<0.05)。病情严重程度与年龄、患2型糖尿病、C反应蛋白水平、IL-6水平呈正相关,而与淋巴细胞、CD3^+细胞、CD4^+细胞及CD8^+细胞计数呈负相关。多因素Logistic回归分析提示,C反应蛋白升高及CD8^+细胞计数降低是重症COVID-19的独立影响因素。结论新型冠状病毒肺炎发热咳嗽为主要症状,C反应蛋白及CD8细胞计数对病情评估有帮助,免疫功能与病情严重程度密切相关。
Objective To analyze the clinical characteristics of 89 cases of coronavirus disease 2019(COVID-19)in Yongchuan Hospital of Chongqing Medical University.Methods The epidemiological data,clinical symptoms and results of laboratory tests of 89 COVID-19 patients admitted in our hospital from January 22 to February 172020 were collected and retrospectively analyzed.Results Fever and cough were the main symptoms of COVID-19,but there were 6 asymptomatic carriers in the cohort.The severe group had significantly lower lymphocyte absolute value,lymphocyte percentage,and the counts of CD3^+,CD4^+and CD8^+cells when compared with the ordinary group(P<0.05).The severe group also had obviously high levels of C-reactive protein and IL-6 than the ordinary and mild groups(P<0.05).The severity of the disease was positively correlated with age,type 2 diabetes,C-reactive protein and IL-6 levels,and negatively correlated with the counts of lymphocytes,CD3^+,CD4^+and CD8^+cells.Multivariate Logistic regression analysis indicated that increased C-reactive protein and decreased CD8^+cell count were independent factors for the severity of the condition.Conclusion Fever and cough are the main symptoms of COVID-19.C-reactive protein and CD8^+cell count are helpful for the assessment of the disease,and immune function is closely related to the severity of the disease.
作者
黄澄澄
庞科
高红丽
HUANG Chengcheng;PANG Ke;GAO Hongli(Department of Geriatrics,Chongqing,402160,China;Ward of Geriatrics and Novel Coronavirus Pneumonia,Chongqing,402160,China;Department of Ultrasonography,Yongchuan Hospital of Chongqing Medical University,Chongqing,402160,China)
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2020年第9期883-886,共4页
Journal of Third Military Medical University
基金
重庆市永川区科技局新型冠状病毒肺炎应急项目(YCSTC2020nb0209)。
关键词
新型冠状病毒肺炎
临床特征
T淋巴细胞
C反应蛋白
白介素6
coronavirus disease 2019
clinical characteristics
T lymphocyte
C-reactive protein
interleukin 6
