摘要
锌指蛋白(zinc-finger protein,ZFP)因其具有指状结构特征且能与锌结合而得名,是真核生物中最重要的转录因子之一。锌指蛋白主要通过与核酸的相互作用,如与单链DNA、RNA结合或RNA/DNA双向结合以及蛋白-蛋白互作来激活或抑制基因的转录,在植物的基因表达与调控、生长发育与衰老、非生物胁迫及生物胁迫等过程中发挥着重要的作用。本文对锌指蛋白转录因子的结构、分类、生物学功能以及调控机制等方面进行了综述,以期为今后锌指蛋白的深入研究提供参考。
Zinc finger protein(ZFP) is one of the most important transcription factors in eukaryotes, which is named because it has fingerlike structure and can combine with zinc. It mainly activate or inhibit gene transcription by interacting with nucleic acids, such as single-stranded DNA, RNA or RNA/DNA binding in both directions, and protein-protein interaction. In plant gene expression and regulation, growth and aging, abiotic stress and biological stress, ZFP also plays an important role. In this paper, the structure,classification, biological function and regulatory mechanism of zinc finger protein transcription factors are reviewed in order to provide reference for further study of zinc finger protein.
作者
李琳
丁峰
潘介春
张树伟
黄幸
王金英
王颖
李浩然
徐炯志
彭宏祥
何新华
LI Lin;DING Feng;PAN Jiechun;ZHANG Shuwei;HUANG Xing;WANG Jinying;WANG Ying;LI Haoran;XU Jiongzhi;PENG Hongxiang;HE Xinhua(College of Agriculture,Guangxi University,Nanning,Guangxi 530004;Institute of Horticulture,Guangxi Academy of Agricultural Science,Nanning,Guangxi 530007;Institute of horticulture,guangxi academy of agricultural sciences,nanning,Guangxi 530007;State key laboratory of conservation and utilization of subtropical agricultural biological resources,nanning,Guangxi 530004)
出处
《热带农业科学》
2020年第2期65-75,共11页
Chinese Journal of Tropical Agriculture
基金
国家自然科学基金(31760564)
广西八桂青年学者专项“国家荔枝龙眼产业技术体系”(No.CARS-33-10)
广西自然科学基金(No.2017GXNSFAA198350,No.2016GXNSFBA380036,No.2018GXNSFAA050089,No.2018GXNSFAA294034)
广西科技重大专项(No.桂科AA17204026)
亚热带农业生物资源保护与利用国家重点实验室开放课题(No.SKLCUSA-b201811)
亚热带农业生物资源保护与利用国家重点实验室自主研究课题(No.SKLCUSA-a201921)。
关键词
锌指蛋白
转录因子
生物学功能
胁迫
调控
ZFP
transcription factor
biological function
stress
regulation
