摘要
目的观察地西他滨+DAG方案(即柔红霉素+阿糖胞苷+重组人粒细胞集落刺激因子)联合扶正解毒化瘀法治疗老年急性髓系白血病(AML)患者的临床疗效和安全性,以及治疗对外周血p53蛋白浓度的影响。方法将80例老年AML患者按照入组先后顺序分为对照组与观察组,每组40例。对照组患者给予地西他滨+DAG方案治疗,观察组在对照组的基础上行扶正解毒祛瘀法治疗。比较2组患者的临床疗效,记录治疗过程中的不良反应。测定患者外周血p53蛋白浓度。结果对照组和观察组中分别有32例和34例患者顺利完成临床治疗。观察组完全缓解率、部分缓解率、客观有效率、总生存时间高于对照组,但差异无统计学意义(P>0.05)。观察组1年生存率高于对照组,差异有统计学意义(P<0.05)。治疗后2组患者的外周血p53蛋白浓度均较治疗前降低,且观察组p53蛋白浓度低于对照组,差异均有统计学意义(P<0.05)。结论地西他滨+DAG方案联合扶正解毒祛瘀法治疗老年AML患者能够提高临床缓解率,且安全性高,其机制可能是通过减少外周血p53蛋白。
Objective To observe the clinical efficacy and safety of a traditional Chinese medicine therapy based on decitabine combined with DAG regimen in elderly patients with acute myeloid leukemia(AML)and the effect of the combined therapy on the p53 protein levels.Methods A total of 80 elderly patients with AML were selected and randomly divided into control and observation groups(n=40 in each group).The patients in the control group were treated with decitabine combined with DAG regimen,and those in the observation group were treated with a traditional Chinese medicine therapy based on decitabine combined with DAG regimen.The clinical efficacy was assessed,the side effects were recorded,and the serum levels of the p53 protein were determined.Results Compared with the control group,the complete remission,partial remission,and objective remission rates,as well as the overall survival time were higher in the observation group,without significant difference.The 1-year survival rate of the observation group was significantly higher than the control group(P<0.05).After treatment,the levels of p53 were significantly lower than before treatment in both groups(P<0.05).Additionally,the levels of p53 were significantly lower in the observation group than in the control group(P<0.05).Conclusion A traditional Chinese medicine therapy based on decitabine combined with DAG regimen can safely improve the remission rate in elderly patients with AML.Its mechanism may be through reducing the serum levels of the p53 protein.
作者
王元
王晓蓓
任爽
WANG Yuan;WANG Xiaobei;REN Shuang(Department of Traditional Chinese Medicine,The First Hospital,China Medical University,Shenyang 110001,China;Deparment of General Practice,The First Hospital,China Medical University,Shenyang 110001,China)
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2020年第5期414-418,共5页
Journal of China Medical University
基金
全国中医临床特色技术传承骨干人才培训项目(国中医药人教函(2018)224号)。
