摘要
目的探讨小儿额叶癫痫患者采用卡马西平联合丙戊酸钠治疗的应用效果。方法选择本院2017年3月至2019年12月收治的小儿额叶癫痫患者60例作为研究对象,按照随机数字表法分为两组,对照组(25例,采用丙戊酸钠治疗),观察组(35例,在对照组基础上联合卡马西平治疗),收集分析两组患者治疗前后癫痫发作情况、智力评分情况和治疗期间不良反应情况。结果治疗前两组患者癫痫发作情况无明显差异(P>0.05),治疗后观察组患者癫痫发作次数为(1.18±0.23)次/d明显低于对照组患者(2.65±0.42)次/d,智力评分为(89.14±2.87)明显高于对照组患者(83.75±3.26),差异均有统计学意义(P<0.05),并且治疗期间两组患者不良反应情况无明显差异(P>0.05)。结论对于小儿额叶癫痫患者采用卡马西平联合丙戊酸钠治疗,能够提高患儿临床治疗效果,治疗安全性较高,值得临床广泛应用。
Objective To explore the effect of carbamazepine combined with sodium valproate in children with frontal lobe epilepsy.Methods 60 cases of pediatric frontal lobe epilepsy treated in our hospital from March 2017 to December 2019 were selected as the research object.They were divided into two groups according to the random number table method,and the control group(25 cases,treated with sodium valproate).The observation group(35 cases,combined with carbamazepine treatment on the basis of the control group),collected and analyzed the seizures,intelligence scores and adverse reactions during and after treatment in the two groups of patients.Results There was no significant difference in seizures between the two groups of patients before treatment(P>0.05).The number of seizures in the observation group after treatment was(1.18±0.23)times/d,which was significantly lower than that in the control group(2.65±0.42)times/d.The intelligence score was(89.14±2.87)significantly higher than that in the control group(83.75±3.26),and the difference was statistically significant(P<0.05),and there was no significant difference in adverse reactions between the two groups during the treatment(P>0.05).Conclusion The use of carbamazepine combined with valproate in children with frontal lobe epilepsy can improve the clinical treatment of children,and it is safe to treat.It is worthy of widespread clinical application.
作者
郭雨帆
GUO Yu-fan(Second Affiliated Hospital of Zhejiang University Medical College,Hangzhou 310000,China)
出处
《中国医药指南》
2020年第14期75-76,共2页
Guide of China Medicine
关键词
卡马西平
丙戊酸钠
小儿
额叶癫痫
治疗效果
Carbamazepine
Sodium valproate
Children
Frontal lobe epilepsy
Treatment effect
