摘要
目的观察温阳散瘀方辅助贝前列素钠片治疗下肢动脉粥样硬化性闭塞症的效果。方法采用简单随机抽样方法从2016年3月至2018年4月于该院接受诊治的下肢动脉粥样硬化性闭塞症患者中选取86例纳入研究,依据随机数字表法进行分组,对照组43例患者接受贝前列素钠片治疗,研究组43例患者接受温阳散瘀方联合贝前列素钠片治疗,治疗6周后评价两组临床疗效,测定两组患者血脂水平、踝肱指数(ABI)、6min步行试验(6-MWT)、无痛行走距离、超敏C反应蛋白(hs-CRP)以及血液流变学相关指标。结果研究组临床总有效率(88.37%)明显高于对照组(69.77%),差异有统计学意义(P<0.05);治疗后两组患者总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平均明显下降(P<0.05),且组间比较差异有统计学意义(P<0.05);治疗后研究组ABI、6-MWT、无痛行走距离和hs-CRP水平均明显优于对照组(P<0.05);治疗后两组血液流变学相关指标均明显下降(P<0.05),且组间比较差异有统计学意义(P<0.05)。结论温阳散瘀方辅助贝前列素钠片应用于下肢动脉粥样硬化性闭塞症的临床治疗,在平衡血脂水平、改善血液流变学相关指标方面效果明显,可有效改善ABI、6-MWT、无痛行走距离和hs-CRP等指标,增进疗效。
Objective To observe the effect of Wenyang Sanyu Formula assisted with Beraprost Sodium Tablet in treating atherosclerotic occlusion of lower extremities.Methods Eighty-six patients with lower extremity atherosclerotic occlusion in this hospital from March 2016 to April 2018 were selected into the study and grouped according to the random number table method.Forty-three cases in the control group received the treatment of Beraprost Sodium Tablets,and 43 cases in the study group were treated with Wenyang Sanyu Formula combined with Beraprost Sodium Tablets.The clinical efficacy after 6-week treatment was evaluated in the two groups.The blood lipid levels,ankle brachial index(ABI),6 min walking test(6-MWT),painless walking distance,high-sensitivity C-reactive protein(hs-CRP)and hemorheology-related indexes were measured in the two groups.Results The total effective rate in the study group was 88.37%,which was significantly higher than 69.77%in the control group,and the difference between the two groups was statistically significant(P<0.05);the levels of total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)after treatment in the two groups were significantly decreased(P<0.05),there was a significant difference between the two groups(P<0.05);ABI,6-MWT,painless walking distance and hs-CRP level after treatment in the study groups were significantly better than those in the control group(P<0.05);the levels of hemorheology-related indexes after treatment in the two groups were decreased significantly,and the differences between the two groups were statistically significant(P<0.05).Conclusion Wenyang Sanyu Formula assisted with Beraprost Sodium Tablet in the clinical treatment of lower extremity atherosclerotic occlusion has obvious effects in the aspects of balancing blood lipid level and improving hemorheology-related indexes,can effectively improve the indexes of ABI,6-MWT,painless walking distance and hs-CRP,and enhance the curative effect.
作者
赵煜辉
甘建雄
师刚刚
ZHAO Yuhui;GAN Jianxiong;SHI Ganggang(Department of Surgery,Xi′an Municipal Hospital of Traditional Chinese Medicine,Xi′an,Shaanxi 710000,China)
出处
《检验医学与临床》
CAS
2020年第10期1394-1397,共4页
Laboratory Medicine and Clinic
关键词
温阳散瘀方
贝前列素钠片
下肢动脉粥样硬化性闭塞症
血脂
血液流变学
Wenyang Sanyu Formula
Beraprost Sodium Tablet
lower extremity atherosclerotic occlusion
blood lipid
hemorheology
