摘要
目的探讨前列腺小体外泄蛋白(PSEP)指标在前列腺癌诊断中的价值。方法2015年3月至2017年3月间收集870例前列腺穿刺活检患者的穿刺前尿样及相关临床资料,采用酶联免疫法检测尿样中PSEP水平,分析尿液PSEP水平和前列腺癌的相关性。结果经病理诊断穿刺阳性370例(前列腺癌患者组),阴性500例(阴性组)。前列腺癌患者的年龄和前列腺特异抗原(PSA)水平均高于阴性组(P<0.05)。前列腺癌患者组穿刺组织中伴随炎症的比例低于阴性组(P<0.05),尿PSEP水平亦低于阴性组(P=0.013)。亚组分析显示在PSA 4~10ng/mL这一区间中,两组之间的尿PSEP水平存在差异(P=0.038)。PSEP水平与前列腺组织学炎症存在相关性(r=0.094,P=0.009)。结论伴随组织学炎症者确诊前列腺癌的风险较低,尿液PSEP水平与前列腺组织学炎症有关,前列腺癌患者尿PSEP水平显著降低,尿液PSEP检测作为辅助指标有助于减少PSA灰区患者因炎症干扰造成的不必要前列腺穿刺活检。
Objective To evaluate the clinical significance of prostatic exosomal protein(PSEP)in the diagnosis of prostate cancer.Methods Urine samples and clinical information were collected from870 patients who underwent prostate needle biopsy during Mar.2015 and Mar.2017.The PSEP level was detected with enzyme-linked immunosorbent assay.The association between PSEP level and prostate cancer was analyzed.Results Of all 870 cases,370 were positive and 500 were negative.Compared with negative cases,prostate cancer cases had advanced age and increased prostate specific antigen(PSA)level(P<0.001),lower incidence of histological inflammation(P<0.05),and lower PSEP level(P=0.013).Subgroup analysis showed that when PSA was 4~10 ng/mL,there was correlation between PSEP level and incidence of histological inflammation(P=0.009,r=0.094).Conclusion Histological inflammation is associated with a low risk of prostate cancer.PSEP level is correlated with histological inflammation.Patients with prostate cancer have decreased PSEP level.Urine PSEP detection may be helpful to avoid unnecessary prostate needle biopsy in patients with PSA4-10 ng/mL.
作者
秦晓健
顾成元
黄永墙
韩成涛
朱耀
戴波
叶定伟
孟洁
QIN Xiao-jian;GU Cheng-yuan;HUANG Yong-qiang;HAN Cheng-tao;ZHU Yao;DAI Bo;YE Ding-wei;MENG Jie(Department of Urology,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032;Department of Urology,Tongren Hospital,Medical School of Shanghai Jiaotong University,Shanghai 200336;Onco Biomedical Technology(Suzhou)Co.,Ltd,Taicang 215411,China)
出处
《现代泌尿外科杂志》
CAS
2020年第5期397-399,共3页
Journal of Modern Urology
基金
国家自然科学基金(No.81702537)。
关键词
前列腺癌
前列腺小体外泄蛋白
炎症
prostate cancer
prostatic exosomal protein
inflammation
