摘要
目的观察鼻内镜下腺样体切除术结合复方头孢克洛治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患儿的临床疗效。方法OSAHS患儿134例,随机分为两组,分别采用鼻内镜腺样体切除术和口服复方头孢克洛治疗(A组69例)和单用复方头孢克洛治疗(B组,65例),比较两组治疗前后症状和生活质量。记录治疗相关并发症的发生情况。结果A组总有效率为95.65%,高于B组的66.15%(P<0.05)。治疗后,A组的丙二醛和硝基酪氨酸水平均低于B组(P<0.05),SOD和谷胱甘肽水平均高于B组(P<0.05)。治疗后,A组的呼吸暂停低通气指数、氧减指数和最长呼吸暂停时间均低于B组(P<0.05),最低夜间血氧饱和度高于B组(P<0.05)。治疗后,A组躯体、心理、社会功能及物质生活等评分均高于B组(P<0.05)。A组治疗相关并发症发生率为4.35%,低于B组的16.92%(P<0.05)。结论与单用复方头孢克洛口服比较,复合应用鼻内镜下腺样体切除术和复方头孢克洛治疗OSAHS患儿的临床疗效较好,并发症发生率低。
Objective To observe the clinical efficacy of endoscopic adenoidectomy combined with compound cefaclor in treating children with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods A total of 134 children with OSAHS was randomly divided into two groups.The patients in group A(69 cases)were treated with combined use of endoscopic adenoidectomy and oral compound cefaclor and those in group B(65 cases)were treated with oral compound cefaclor alone.The clinical symptoms,quality of life after treatment were compared between the two groups.The treatment-related complications were recorded.Results The overall effectiveness rate of group A was 95.65%,which was higher than 66.15%of group B(P<0.05).The levels of malondialdehyde and nitrotyrosine after treatment were lower in group A than those in group B(P<0.05).The levels of SOD and glutathione were higher in group A than those in group B(P<0.05).The respiratory disorders index,oxygen reduction index and maximum apnea time after treatment were lower in group A than those in group B(P<0.05).The lowest nocturnal blood saturation after treatment was higher in group A than that in group B(P<0.05).After treatment,the scores of body,psychology,social function and material life in group A were higher than those in group B(P<0.05).The incidence of complications associated with treatment in group A was 4.35%,which was lower than 16.92%in group B(P<0.05).Conclusion Compared with compound cefaclor oral administration alone,the combined use of intranasal endoscopic adenoidectomy and compound cefaclor in the treatment of children with OSAHS has better clinical efficacy and lower incidence of complications.
作者
朱丹丹
张守德
ZHU Dandan;ZHANG Shoude(Department of Otolaryngoloy,Xianju County People’s Hospital,Xianju 317300,CHINA)
出处
《江苏医药》
CAS
2020年第4期389-392,共4页
Jiangsu Medical Journal
