摘要
线粒体呼吸链超级复合体(mitochondrial respiratory chain supercomplex, mitoSC)是线粒体内膜呼吸链上的自由复合体通过其亚基之间的相互作用形成的复合体超级组装,主要为mitoSCⅠ1+Ⅲ2+Ⅳ1-4、mitoSCⅠ1+Ⅲ2、mitoSCⅢ2+Ⅳ1-2、高分子量mitoSC (high molecular weight mitoSC, HMW mitoSC)和巨型超级复合体(mitochondrial metacomplex, mitoMC)。mitoSC已被证明具有提高呼吸链电子传递效率、减少活性氧产生的功能。在衰老的不同组织和诸多线粒体相关疾病组织中,mitoSC的种类和含量发生变化。本文通过归纳人类和哺乳动物不同组织中mitoSC的结构和功能,总结衰老、心脏疾病、2型糖尿病、癌症和基因缺陷疾病等条件下mitoSC的变化规律,重点探讨运动对mitoSC的影响及其相关调节机制,为线粒体相关疾病的运动干预提供参考。
The mitochondrial respiratory chain supercomplex(mitoSC) is a complex super-assembly formed by free complexes on the mitochondrial inner membrane respiratory chain through the interaction between their subunits, mainly including mitoSCⅠ1+Ⅲ2+Ⅳ1-4, mitoSCⅠ1+Ⅲ2, mitoSCIII2+Ⅳ1-2, high molecular weight mitoSC(HMW mitoSC) and mitochondrial metacomplex(mitoMC). mitoSC has been shown to improve the efficiency of electron transport in the respiratory chain and reduce the production of reactive oxygen species. The species and content of mitoSC change in different tissues in aging and many mitochondria-related diseases. By summarizing the structure and function of mitoSC in different tissues of human and mammals, and the changes of mitoSC under conditions of aging, heart disease, type 2 diabetes, cancer and genetic defects, this review focuses on the effects of exercise on mitoSC and its related regulation mechanisms in order to offer an insight for exercise interventions in mitochondria-related diseases.
作者
王艳
薄海
张勇
WANG Yan;BO Hai;ZHANG Yong(School of Sports Science,Beijing Sport University,Beijing 100084,China;Deparlmen1 of Military Training Medicines,Logistics University of Chinese People's Armed Police Force,Tianjin 300162,China;Tianjin Key Laboratory of Exercise Physiology and Sports Medicine,Research Center for Exercise&Health Science,Tianjin University of Sport,Tianjin 310617,China)
出处
《生理学报》
CAS
CSCD
北大核心
2020年第2期205-219,共15页
Acta Physiologica Sinica
基金
Research from the corresponding author's laboratory was supported by grants from the National Natural Science Foundation of China(No.31771320,31571224,31110103919).
关键词
线粒体呼吸链超级复合体
运动
活性氧
电子传递
线粒体相关疾病
mitochondrial respiratory chain supercomplex
exercise
reactive oxygen species
electron transport
mitochondria-related diseases
