摘要
目的观察丙氨酰谷氨酰胺联合乌司他丁治疗重症急性胰腺炎的临床效果。方法选取2018年1月-2019年9月郴州市第一人民医院南院收治的重症急性胰腺炎患者120例,采用随机数表法分为观察组和对照组各60例。对照组采用常规治疗,观察组在常规治疗的基础上采用丙氨酰谷氨酰胺联合乌司他丁治疗。比较2组患者的治疗效果、治疗前后炎性因子水平及肝肾功能改善情况。结果观察组的治疗总有效率为93.33%,高于对照组的70.00%(χ~2=10.909,P<0.01)。治疗后2组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)、天门冬氨酸氨基转肽酶(AST)、丙氨酸氨基转肽酶(ALT)、总胆红素(TBil)及血清肌酐(SCr)水平均低于治疗前(P<0.05),且观察组低于对照组(P<0.05)。结论丙氨酰谷氨酰胺联合乌司他丁治疗重症急性胰腺炎的临床效果较好,可降低患者的炎性因子水平,改善患者的肝肾功能,缩短患者的症状缓解时间,促进患者病情的快速康复。
Objective To observe the clinical effect of alanyl glutamine combined with ulinastatin in the treatment of severe acute pancreatitis.Methods 120 cases of severe acute pancreatitis treated in the South Hospital of Chenzhou First People’s Hospital from January 2018 to September 2019 were selected.Random number table method was used to divide the observation group and control group,each of 60 cases.The control group was treated with conventional treatment,and the observation group was treated with alanylglutamine combined with ulinastatin on the basis of conventional treatment.The treatment effects,before and after treatment inflammatory factor levels,liver and kidney function improvement were compared.Results The total effective rate of treatment in the observation group was 93.33%,which was higher than 70.00%in the control group(χ~2=10.909,P<0.01).After treatment,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP),aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBil)and serum creatinine(SCr)levels were lower than before treatment(P<0.05),and the observation group were lower than the control group(P<0.05).Conclusion Alanylglutamine in combination with ulinastatin has a good clinical effect in treating severe acute pancreatitis,which can reduce the level of inflammatory factors in patients,improve the liver and kidney function of patients,shorten the time to relieve symptoms of patients,and promote rapid disease Rehabilitation.
作者
黄文超
HUAGN Wenchao(South Hospital of Chenzhou First People's Hospital^Hunan Province,Chenzhou 423000,China)
出处
《临床合理用药杂志》
2020年第11期8-9,22,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
丙氨酰谷氨酰胺
乌司他丁
重症急性胰腺炎
炎性因子
肝肾功能
Alanylglutamine
Ulinastatin
Severe acute pancreatitis
Inflammatory factors
Liver and kidney function
