摘要
目的观察消渴痹足浴方联合西洛他唑对糖尿病周围神经病变(DPN)患者的临床疗效及对患者运动神经传导速度的影响。方法将丽水市中医院2017年1月-2019年3月收治的112例DPN患者根据治疗方法不同分为西洛他唑组(56例)和联合组(56例)。2组均予以常规基础干预及西洛他唑治疗;联合组加用消渴痹足浴方泡足。2组患者均连续治疗8周。观察2组治疗效果、不良反应。采用多伦多临床评分量表(TCSS)评价2组治疗前后症状严重程度。比较2组治疗前后正中神经和腓总神经的运动神经传导速度(MNCV)和感觉神经传导速度(SNCV)。结果联合组治疗后TCSS评分明显低于西洛他唑组[(4.95±1.37)分vs.(6.38±2.02)分],正中神经MNCV[(50.97±4.28)m/s vs.(47.43±4.15)m/s]和SNCV[(46.05±4.24)m/s vs.(50.44±5.27)m/s]、腓总神经MNCV[(45.27±4.11)m/s vs.(42.34±3.93)m/s]和SNCV[(39.92±5.17)m/s vs.(43.02±5.62)m/s]以及治疗总有效率(94.64%vs. 73.21%)明显高于西洛他唑组,差异均有统计学意义(均P<0.05)。结论消渴痹足浴方联合西洛他唑可有效缓解DPN临床症状,改善病变神经的传导速度,临床效果显著,安全性好。
Objective To observe the clinical effect of Xiaokebizu Bath Prescription combined with cilostazole on diabetic peripheral neuropathy(DPN) and the effect on motor nerve conduction velocity. Methods A total of 112 patients with DPN admitted to our hospital from January 2017 to March 2019 were selected and divided into cilostazol group(56 cases) and combination group(56 cases) according to the different treatment methods. Both groups were given routine basic intervention and cilostazol treatment. The combined group was treated with Xiaokebizu Bath Prescription. Both groups were treated for 8 weeks. The therapeutic effects and adverse reactions of the two groups were observed. Toronto Clinical Score Scale(TCSS) was used to evaluate the severity of symptoms before and after treatment. The motor nerve conduction velocity(MNCV) and sensory nerve conduction velocity(SNCV) of median nerve and common peroneal nerve were compared between the two groups before and after treatment. Results The TCSs score of the combined group was significantly lower than that of the cilostazol group [(4.95±1.37) scores vs.(6.38±2.02) scores]. The MNCV [(50.97±4.28) m/s vs.(47.43±14.15) m/s] and SNCV [(46.05±14.24) m/s vs.(50.44±15.27) m/s] of the median peroneal nerves, the MNCV [(45.27±14.11) m/s vs.(42.34±13.93) m/s] and SNCV [(39.92±15.17) m/s vs.(43.02±15.62) m/s] of the nervus peroneus communis and total effective rate(94.64% vs. 73.21%) in the combined group were significantly higher than those in the cilostazol group(all P<0.05). Conclusion Xiaokebizu Bath Prescription combined with cilostazol can effectively alleviate the clinical symptoms of DPN patients and improve the conduction velocity of diseased nerves. The clinical effect is remarkable and the safety is good.
作者
兰静
丁世玲
赖立英
张征宇
LAN Jing;DING Shi-ling;LAI Li-ying;ZHANG Zheng-yu(Department of Rehabilitation,Lishui City Hospital of Traditional Chinese Medicine,Lishui,Zhejiang 323000,China;不详)
出处
《中华全科医学》
2020年第6期1018-1020,共3页
Chinese Journal of General Practice
基金
浙江省中医药科技计划项目(2017ZA145)。
关键词
糖尿病周围神经病变
消渴痹足浴方
西洛他唑
疗效
Diabetic peripheral neuropathy
Xiaokebizu bath prescription
Cilostazol
Efficacy
