摘要
运用中医药超分子“气析”理论,结合新型冠状病毒感染的肺炎(COVID-19)的特点,回顾性分析中医治疗疫病理论产生与发展的历史源流、特点,提出实现现代化的关键科学问题,阐明其解决对策。中医疫病理论的产生和发展史实际上就是对戾气致病的生物超分子化学的科学认识史,由“非时之气”到戾气的病因探求,由六经辨证论治发展到卫气营血、三焦辨证论治,逐渐接近现代传染病学和免疫学理论体系,均具有中医药超分子“气析”理论的印迹。将严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2,戾气),人体与中药置于自然界生物演化的历程中,三者都是自然界中处于特定进化阶段的生物超分子体,均受到逐级生物超分子的“分子社会”按“印迹模板”管控;彼此进化、突变、适应、制约的规律一直未变。通过对隐藏在中医药疫病防治理法方药的超分子作用规律进行分析,探讨其现代化关键科学问题并提出解决策略,既可阐明中医药疫病防治的科学原理,研制出组分中药,加速疫情控制,还可带动中医药经络脏腑与证候物质基础、中药复方配伍规律等原创性关键前沿科学问题的解决。
In this paper,based on the supramolecular "Qi chromatography" of traditional Chinese medicine(TCM),combined with the characteristics of corona virus disease 2019(COVID-19),the historical origin and characteristics of theoretical research on the treatment of epidemic diseases by TCM were analyzed retrospectively, and the key scientific problems for achieving its modernization were proposed, and the countermeasures were illustrated. In fact,the emergence and development history of TCM epidemic theory is a comprehensive and scientific understanding of biomolecular chemistry for epidemic caused by pathogen. From the exploration of the cause of abnormal Qi to the epidemic pathogenic factor,from the treatment based on syndrome differentiation by six meridians to by the defensive Qi and nutrient blood and the triple energizer,which is gradually close to the modern theoretical system of infectious diseases and immunology,all of which are stamped with brand of TCM supramolecular "Qi chromatography" theory. In the long history of biological evolution in nature,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)as epidemic pathogenic factor in TCM,human body and Chinese materia medica are biological supramolecules at a specific stage of evolution in nature, which are controlled by the "imprinting templates" of molecular society in gradual biomolecules,with the unchanged laws of mutual advancement,mutation,suitability and mutual restriction.Based on the analysis of the law of supramolecular action hiding in the prevention and treatment of epidemic diseases dealt with TCM on procession of principle-method-recipe-medicines,this paper discusses the key scientific problems of its modernization and puts forward the solutions. It can not only clarify the scientific principle of the prevention and treatment with TCM,develop the multi-component Chinese medicine,accelerate the control of the epidemic situation,but also promote the solution of original frontier key scientific problems such as the material basis of meridians, viscera and syndromes, and the compatibility law of the TCM prescription,in order to protect the existing medical resources and open up a new situation in the modernization of TCM research.
作者
邓凯文
刘文龙
樊启猛
潘雪
周逸群
李海英
贺鹏
贺玉婷
贺福元
DENG Kai-wen;LIU Wen-long;FAN Qi-meng;PAN Xue;ZHOU Yi-qun;LI Hai-ying;HE Peng;HE Yu-ting;HE Fu-yuan(The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China;Property and Pharmacodaynamic Key Laboratory of Traditional Chinese Medicine(TCM),National Administration of TCM,Laboratory of Supramolecular Mechanism and Mathematic-physics Characterization for TCM,Processing and Pharmaceutical Preparation Engineering Technological Laboratory of Chinese Materia Medica,Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Chinese Materia Medica,College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第11期28-34,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81573691,81874507)
湖南省教育厅创新平台开放基金项目(18K071)
长沙市科技计划项目(kq1907137)。
