摘要
目的:探讨急性重症胰腺炎(SAP)患者血清降钙素原(PCT)、二胺氧化酶(DAO)水平与急性生理与慢性健康(APACHEⅡ)评分的相关性及其临床意义。方法:以60例SAP患者为观察组,其中APACHEⅡ评分<10分19例,10~19分26例,≥20分15例,另选取同期健康体检者26例为对照组。比较两组间、SAP不同APACHEⅡ评分患者间血清PCT、DAO水平的差异,分析血清PCT、DAO水平与SAP患者APACHEⅡ评分的相关性。结果:观察组血清PCT 27.40±3.56 pg/mL,DAO 2.81±0.77 U/mL,分别高于对照组的10.49±2.03 pg/mL和1.09±0.22 U/mL,差异均有统计学意义(P<0.001)。APACHEⅡ评分<10分患者血清PCT为19.56±2.47 pg/mL,DAO为2.11±0.43 U/mL,分别低于10~19分患者的29.44±3.06 pg/mL和2.88±0.57 U/mL,10~19分患者血清PCT、DAO分别低于≥20分患者的33.21±3.58 pg/mL和3.44±0.61 U/mL,差异均有统计学意义(P<0.05)。血清PCT(r=0.622,P<0.001)、DAO(r=0.649,P<0.001)水平与SAP患者APACHEⅡ评分呈正相关。结论:SAP患者血清PCT、DAO水平异常升高,与APACHEⅡ评分存在正相关,动态监测血清PCT、DAO水平有助于临床判断SAP患者病情进展及严重程度。
Objective:To investigate the correlation between serum levels of procalcitonin(PCT)and diamine oxidase(DAO)and acute physiology and chronic health(APACHEⅡ)scores in patients with acute severe pancreatitis(SAP)and its clinical significance in dynamic monitoring.Methods:Sixty SAP patients admitted by our hospital were selected as the study group,and 26 healthy people who were examined during the same period were selected as the control group.Detection and comparison of serum PCT and DAO levels between different APACHEⅡscores(Twenty or more,ten to nineteen,less than ten)in the two groups and the study group.The correlation between serum PCT and DAO levels and APACHEⅡscores of SAP patients was analyzed.Results:The levels of serum PCT and DAO in the study group were higher than those in the control group(P<0.05);The serum PCT and DAO levels of the study group with an APACHEⅡscore less than ten are lower than the APACHEⅡscore of ten to nineteen points,serum PCT and DAO levels of APACHEⅡscore of ten to nineteen are lower than APACHEⅡscore of greater than or equal to twenty(P<0.05);Spearman analysis showed that there was a significant positive correlation between serum PCT and DAO levels and APACHEⅡscores in SAP patients(r1=0.622,P1<0.001;r2=0.649,P2<0.001).Conclusion:The serum PCT and DAO levels of SAP patients are abnormally highly expressed.There is a significant positive correlation between serum PCT and DAO levels and APACHEⅡscore,dynamic monitoring of serum PCT and DAO levels is helpful for clinical judgment of SAP patients’disease progression and severity.
作者
薛全胜
丁益宏
XUE Quansheng;DING Yihong(Department of Gastroenterology,Rugao People’s Hospital,Jiangsu 226500)
出处
《交通医学》
2020年第2期143-144,149,共3页
Medical Journal of Communications
