摘要
以丙二酸和异戊醛为原料经过缩合、脱羧得到5-甲基-2-己烯酸乙酯,再经过迈克尔加成、脱羧、水解得到3-异丁基戊二酸,该合成工艺总收率为89%。该法收率高、操作简便、易于工业化生产。
3-isobutylglutaric acid was obtained with an overall yield of 89 %, from malonic acid and isovaleraldehyde via condensation, decarboxylation to give 3-isobutylglutaric acid, which was subjected to Michael addition, decarboxylation and hydrolysis. The synthesis is simple, easily controlled and high yield for the industrial production.
作者
尤海烽
王菲
张乔乔
祁秀秀
陈文华
You Haifeng;Wang Fei;Zhang Qiaoqiao;Qi Xiuxiu;Chen Wenhua(Dept.of Chemical and Pharmaceutical Engineering,Changzhou Vocation College of Engineering and Technology,Changzhou 213164,China)
出处
《广东化工》
CAS
2020年第10期52-52,共1页
Guangdong Chemical Industry
基金
江苏省青蓝工程项目(2018)
江苏省产学研合作项目(BY2019155)
江苏省“双创计划”科技副总项目(FZ20190353)。
关键词
丙二酸
异戊醛
3-异丁基戊二酸
普瑞巴林
Malonic acid
isovaleraldehyde
3-isobutylglutaric acid
Pregabalin
