摘要
他汀类药物是一种3-羟基-3-甲戊二酸单酰辅酶A还原酶抑制剂,常用于血脂异常相关的心脑血管疾病的防治。其主要的不良反应为肌肉毒性,可引起各种骨骼肌相关不良反应,包括轻微的肌肉疼痛以及较严重的横纹肌溶解症等。通过检索近年来他汀类药物相关肌肉症状的流行病学、临床特征、作用机制、防治方法,总结了关于他汀类药物引起的肌肉不良反应的最新研究进展,旨在为该类药物的临床安全用药,以及后期研究提供依据。
Statins are 3-hydroxy-3-methylglutaryl-coenzyme A(HMG-CoA) reductase inhibitors, commonly used for the prevention of cardiovascular diseases associated with dyslipidemia. The main adverse reaction of statins is muscle toxicity, which may induce skeletal muscle-related symptoms, including mild myalgia and severe rhabdomyolysis. This paper summarizes the advances in the studies of statin-induced muscle symptoms based on recent literature on epidemiology, clinical features, mechanism of action, and treatment of statin-associated muscle symptoms, so as to provide evidence for clinical safety and further studies of statins.
作者
何瑞
徐志猛
王来
李萍
闻晓东
HE Rui;XU Zhimeng;WANG Lai;LI Ping;WEN Xiaodong(State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China)
出处
《药学进展》
CAS
2020年第4期303-312,共10页
Progress in Pharmaceutical Sciences
