摘要
目的探讨血浆D-二聚体水平与肺癌分期、病理类型及预后的相关性。方法选取84例肺癌患者作为肺癌组,选取同期80例健康体检者作为对照组,检测2组血浆D-二聚体水平,分析不同肺癌分期、病理类型血浆D-二聚体水平,并评估化疗效果。结果肺癌组患者血浆D-二聚体水平高于对照组(P<0.05);肺癌分期越晚,血浆D-二聚体水平越高(P<0.05);不同病理类型肺癌D-二聚体水平差异无显著性(P>0.05);治疗后,除疾病进展组患者D-二聚体水平较之前升高,其他组均低于治疗前,差异有统计学意义(P<0.05)。结论血浆D-二聚体水平与肺癌分期具有较高相关性,可作为判断肺癌病情发展及预后的生物学指标。
Objective To investigate the correlation between plasma D-dimer level and stage,pathological type and prognosis of lung cancer.Methods 84 lung cancer patients were selected as the lung cancer group,and 80 healthy medical examinees during the same period were selected as the control group.The plasma D-dimer levels of two groups were detected.The plasma D-dimer levels of different lung cancer stages and pathological types were analyzed,and the effect of chemotherapy was evaluated.Results The plasma D-dimer level in the lung cancer group was higher than that in the control group(P<0.05).The later lung cancer stage,the higher plasma D-dimer level(P<0.05);There was no significant difference in the level of D-dimer in lung cancer of different pathological types(P>0.05).After treatment,the D-dimer level of patients in the disease progression group was higher than that before treatment,and the levels of the other groups were lower than those before treatment,and the difference was statistically significant(P<0.05).Conclusion Plasma D-dimer level has a high correlation with lung cancer staging,which can be used as a biological indicator to judge the development and prognosis of lung cancer.
作者
邓梅毓
赵建清
DENG Mei-yu;ZHAO Jian-qing(Graduate School of Hebei North University,Zhangjiakou,Hebei 075000,China;The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China)
出处
《河北北方学院学报（自然科学版）》
2020年第8期5-7,共3页
Journal of Hebei North University:Natural Science Edition
关键词
肺癌
血浆D-二聚体
分期
病理类型
预后
lung cancer
plasma D-dimer
staging
pathological type
prognosis
