摘要
目的为系统研究不同初配日龄对NIH小鼠繁殖性能的影响。方法本试验按初配日龄分为4组,50、60、70、85 d各30对小鼠,记录了每对小鼠第1~6胎的繁殖性能。结果70、85 d组在产仔数、离乳数、离乳率、出生及离乳仔鼠平均体重与50 d组有显著或极显著差异(P<0.05,P<0.01);与60 d组比在出生仔鼠平均体重、离乳数有显著差异(P<0.05);各组胎间隔无差异性(P>0.05);NIH小鼠第2~3胎平均产仔数与第1胎比具有明显升高(P<0.05),第5~6胎显著下降(P<0.05);第3~4胎离乳数与第1胎相比有差异性(P<0.05);出生仔鼠平均体重、离乳率随胎次增加而增加(P<0.05,P<0.01),离乳仔鼠平均体重无显著差异(P>0.05)。结论NIH小鼠在70~85日龄初配繁殖性能较好,第2~3胎繁殖性能稳定,建议繁殖至第6胎。
Objective We systematically studied the effects of initial mating age on reproductive performance in NIH mice.Methods Thirty pairs of mice were divided into 4 groups according to initial mating age:50,60,70,or 85 days old.For the first to sixth litters from each pair,we recorded the average litter size,number of weaned mice,weight of the natal mice and weaned mice,and calculated the weaning rate and day,and compared these between the age groups.Results Compared with the 50-day-old group,the 70-and 85-day-old groups were significantly or extremely significantly different in terms of the average litter size,number of weaned mice,weaning rate,and weight of the natal mice and weaned mice(P<0.05,P<0.01).Compared with the 60-day-old group,the 70-and 85-day-old groups were significantly different in terms of average body weight and the number of weaned mice(P<0.05).There were no differences in the intervals between litters among the groups(P>0.05).The average litter size in NIH mice for the second and third litters was significantly higher than that for the first litter(P<0.05).The fifth and sixth litters had a significantly decreased average size(P<0.05).The number of weaned mice in the third and fourth litters was different from that in the first litter(P<0.05).The average body weight and lactation rate of the mother increased with the age of parity(P<0.05,P<0.01).The average body weight and weaning rate of the infant mice increased with the age of parity.There were no significant differences in the average body weight of the weaned mice(P>0.05).Conclusions NIH mice have better reproductive performance at 70~85 days of age,and the second and third births are stable in terms of reproductive performance.For propagation of research animals,up to six litters are recommended.
作者
李楠
王从武
王天奇
何嘉玲
暴国
张长勇
孙德明
LI Nan;WANG Congwu;WANG Tianqi;HEJialing;BAO Guo;ZHANG Changyong;SUN Deming(National Research Institute for Family Planning,Beijing 100081,China;Zhongmu Industrial Co.,Ltd.,Beijing 100070)
出处
《中国比较医学杂志》
CAS
北大核心
2020年第5期64-67,共4页
Chinese Journal of Comparative Medicine
基金
中央级公益性科研院所基本科研业务专项资金重点项目(2018GJZ03)
中央级公益性科研院所基本科研业务专项资金重点项目(2019GJZ09)。
