摘要
目的探讨一清胶囊联合曲安奈德对扁平苔藓患者的临床疗效。方法选取2017年5月-2018年7月秦皇岛市第一医院收治的78例口腔黏膜扁平苔藓患者作为研究对象,按照就诊顺序随机分为对照组与观察组,每组各39例。对照组患者采用曲安奈德注射液10 mg,加入2%盐酸利多卡因1 mL混合,制成悬浊液,注射于口腔粘膜病损区基底部,1次/10 d。观察组在对照组治疗的基础上口服一清胶囊,2粒/次,3次/d。两组患者均连续治疗3个月。观察两组患者的临床疗效,比较治疗前后两组患者口腔黏膜症状面积、疼痛程度评分、Th1、Th2、Th1/Th2比值、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-2、IL-10水平和1年复发率。结果治疗后,观察组患者的总有效率为92.31%,显著高于对照组的69.23%,差异有统计学意义(P<0.05)。治疗后,两组患者的溃疡、糜烂、白纹面积及VAS评分均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,观察组患者的溃疡、糜烂、白纹面积及VAS评分均显著低于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者的Th1、Th2及Th1/Th2水平均降低,同组比较差异有统计学意义(P<0.05),治疗后,观察组患者的Th1、Th2及Th1/Th2水平明显较对照组低,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者的血清TNF-α、IL-2及IL-10水平均显著降低,同组比较差异有统计学意义(P<0.05),与对照组比较,治疗后观察组患者的TNF-α、IL-2及IL-10水平较低,两组比较差异有统计学意义(P<0.05)。治疗后1年,观察组患者的复发率为10.26%,显著低于对照组的51.28%,两组比较差异有统计学意义(P<0.05)。结论一清胶囊联合曲安奈德治疗口腔扁平苔藓可有效降低患者症状面积,减轻疼痛,调节机体Th1/Th2平衡,降低炎性反应,同时可提高临床疗效,降低复发率。
Objective To explore the clinical effects of Yiqing Capsules combined with triamcinolone acetonide in treatment of lichen planus.Methods Patients(78 cases)with lichen planus in First Hospital of Qinhuangdao from May 2017 to July 2018 were divided into control group and observation group according to the order of visit,with 39 cases in each group.Patients in the control group were given Triamcinolone Acetonide Injection of 10 mg,mixed with 2%lidocaine hydrochloride 1 mL.The suspension was injected into the base of the lesion area of oral mucosa,once for 10 days.Patients in the observation group were po administered with Yiqing Capsules on the basis of control group,2 pills/time,three times daily.Patients in two groups were treated continuously for 3 months.The clinical efficacy in two groups was observed,and the oral mucosal symptom area,pain degree score,Th1,Th2,Th1/Th2 ratio,TNF-α,IL-2,IL-10 levels,and 1-year recurrence rate in two groups were compared before and after treatment.Results After treatment,the total effective rate of patients in the observation group was 92.31%,significantly higher than 69.23%of the control group,and the difference was statistically significant(P<0.05).After treatment,the ulcer,erosion,white grain area,and VAS score in two groups were significantly reduced,and the differences before and after treatment were statistically significant(P<0.05).After treatment,the ulcer,erosion,white grain area,and VAS score in the observation group were significantly lower than those in the control group,and the difference between two groups was statistically significant(P<0.05).After treatment,the levels of Th1,Th2,and Th1/Th2 in two groups were decreased,and there was a significant difference in the same group(P<0.05).After treatment,the levels of Th1,Th2,and Th1/Th2 in the observation group were significantly lower than those in the control group,and there was a significant difference between the two groups(P<0.05).After treatment,the serum levels of TNF-α,IL-2,and IL-10 in two groups were significantly reduced,the difference before and after treatment in the same group was statistically significant(P<0.05).Compared with the control group,the levels of TNF-α,IL-2,and IL-10 in the observation group after treatment were lower,with statistically significant differences between the two groups(P<0.05).One year after treatment,the recurrence rate of the observation group was 10.26%,significantly lower than 51.28%of the control group,the difference between the two groups was statistically significant(P<0.05).Conclusions Yiqing Capsules combined with triamcinolone acetonide in treatment of oral lichen planus can effectively reduce the patient’s symptom area,relieve pain,regulate the Th1/Th2 balance of the body,reduce the inflammatory response,and improve the clinical efficacy and reduce the recurrence rate.
作者
孙娜
刘建捷
SUN Na;LIU Jianjie(Department of Stomatology,First Hospital of Qinhuangdao,Qinhuangdao 066000,China)
出处
《药物评价研究》
CAS
2020年第5期907-911,共5页
Drug Evaluation Research
基金
秦皇岛市科学技术研究与发展计划项目(201805A 102)。
