摘要
目的探讨补阳还五汤联合中药离子导入对消渴痹病患者的临床疗效。方法选择消渴痹病患者96例进行研究,依随机数字表法分为2组,各48例。对照组予补阳还五汤加减治疗,观察组在对照组基础上加以中药离子导入治疗。比较2组临床疗效、临床症状、神经传导速度、氧化应激反应、血管活性因子及安全性指标。结果观察组有效率为95.83%,明显高于对照组的83.33%(P<0.05)。干预后2组患者多伦多临床神经病变评分及中医证候积分均明显下降,观察组下降幅度更为明显(P<0.05)。干预后2组患者正中神经及腓总神经的运动神经传导速度与感觉神经传导速度、一氧化氮水平、血清总抗氧化能力、丙二醛均明显升高,观察组升高幅度更大(P<0.05)。2组患者超氧化物歧化酶、内皮素及血管内皮生长因子均明显下降,但观察组下降更明显(P<0.05)。对照组出现2例(4.17%)不良反应,与观察组出现的1例(2.08%)比较,差异无统计学意义(P>0.05)。结论补阳还五汤联合中药离子导入较单独使用补阳还五汤可明显提高气虚血瘀型消渴痹病患者疗效,其作用机制可能与增加正中神经及腓总神经传导速度、缓解氧化应激反应、降低内皮素及血管内皮生长因子水平及升高一氧化氮水平有关。
Objective To explore the effect of Buyang Huanwu decoction combined with traditional Chinese medicine iontophoresis on patients with consumptive thirst involving Bi disease.Methods A total of 96 patients with consumptive thirst involving Bi disease were divided into two groups,48 cases each according to the random number table method.The control group was treated with Buyang Huanwu decoction,and the observation group was given Chinese medicine iontophoresis on this basis.The clinical efficacy,clinical symptoms,nerve conduction velocity,oxidative stress response,vasoactive factors and safety indicators were compared between the two groups.Results The effective rate of the observation group was 95.83%,which was significantly higher than that of the control group (83.33%) (P<0.05).After intervention,the scores of clinical neuropathy scores and TCM syndromes in the two groups were significantly decreased,but the decline was more significant in the observation group (P<0.05).After intervention,the motor nerve conduction velocity and sensory nerve conduction velocity,nitric oxide level,serum total antioxidant capacity,and malondialdehyde in the median and common peroneal nerves of the two groups were significantly increased,but the observation group increased more (P<0.05).Superoxide dismutase,endothelin and vascular endothelial growth factor were significantly decreased in the two groups,but the decrease was more significant in the observation group (P<0.05).There were 2 cases (4.17%) of adverse reactions in the control group,and there was no significant difference between the two groups (2.08%) in the observation group (P>0.05).Conclusion Buyang Huanwu decoction combined with iontophoresis of traditional Chinese medicine can significantly improve the curative effect of consumptive thirst involving Bi disease of qi deficiency and blood stasis type compared with the single use of Buyang Huanwu Decoction.Its mechanism may be related to increasing the conduction velocity of median nerve and common peroneal nerve,alleviating oxidative stress response,reducing the levels of endothelin and vascular endothelial growth factor,and increasing the level of nitric oxide.
作者
尤鲁山
田君义
朵生兰
YOU Lushan;TIAN Junyi;DUO Shenglan(Department of Diabetes,Chengbei District Traditional Chinese Medicine Hospital,Xining City,Qinghai Province,Xining 810003,China;Department of Ultrasound,Qinghai Red Cross Hospital,Xining 810000,China)
出处
《吉林中医药》
2020年第5期635-638,共4页
Jilin Journal of Chinese Medicine
基金
青海省自然科学基金项目(132810045101230)。
关键词
消渴痹病
补阳还五汤
中药离子导入
气虚血瘀
consumptive thirst involving Bi disease
Buyang Huanwu decoction
traditional Chinese medicine iontophoresis
qi defi ciency and blood stasis
