摘要
目的应用RISK21框架和工具分析我国2~6岁儿童邻苯二甲酸二(2-乙基)己基酯(DEHP)、邻苯二甲酸二丁酯(DBP)、邻苯二甲酸二异壬酯(DINP)、邻苯二甲酸丁基苄基酯(BBP)、邻苯二甲酸二异丁酯(DIBP)、邻苯二甲酸二甲酯(DMP)、邻苯二甲酸二乙酯(DEP)7种邻苯二甲酸酯类物质(PAEs)的膳食暴露风险,为风险管理决策提供科学基础。方法以PAEs的毒性为纵坐标,以暴露为横坐标,以暴露限值(MOE)和不确定系数为参数,应用RISK21工具中RISK PLOT模块,通过矩阵计算,以图形展示2~6岁儿童暴露于7种PAEs的风险大小和等级。应用TTC PLOT模块,分析毒理学资料缺乏的DMP、DEP、DIBP 3种PAEs的暴露风险。结果 RISK PLOT表明一般人群7种PAEs均处于风险较低的绿色区域;高食物消费量人群7种PAEs暴露风险排序为DBP、DIBP、DEHP、DMP、DEP、DINP及BBP, TTC PLOT显示我国2~6岁儿童DMP、DEP、DIBP膳食暴露风险低于相应的毒理学关注阈值(TTC)。结论 RISK21框架和工具可应用于风险评估及其后期的管理决策, RISK21分析结果表明我国2~6岁儿童7种PAEs膳食暴露风险较低。
Objective To analyze the risks of dietary exposure of diethylhexyl phthalate(DEHP), dibutyl phthalate(DBP), diisononyl phthalate(DINP), butylbenzyl phthalate(BBP), diisobutyl phthalate(DIBP), dimethyl phthalate(DMP) and diethyl phthalate(DEP) to 2-6 years children in China using RISK21, so as to provide risk management strategy for phthalic acid esters(PAEs). Methods RISK PLOT module was used to analyze and rank risks, with toxicity as Y-axis and exposure as X-axis and margin of exposure(MOE) and uncertainty factor as parameters. Matrix calculation was conducted, risks level and rank of 7 kinds of PAEs to 2-6 years children were illustrated by visualized graphs. TTC PLOT module was used to analyze risks of DMP, DEP and DIBP, which were lacking of toxicity data. Results RISK PLOT showed that the risks of 7 kinds of PAEs for general population located in the green area, which demonstrated that they had low risk to 2-6 years children, and the risks of high food consumption population ranked in descending order were DBP, DIBP, DEHP, DMP, DEP, DINP and BBP. TTC PLOT showed that the risks of DMP, DEP and DIBP were lower than the corresponding threshold of toxicological concern(TTC) that demonstrated low risks. Conclusion RISK21 framework and tools could be a very useful tool for risk assessment and further risk management, and low risks of dietary exposure of 7 kinds of PAEs to 2-6 years children in China by RISK21 analyzing.
作者
包汇慧
毛伟峰
宋雁
刘兆平
隋海霞
张磊
BAO Huihui;MAO Weifeng;SONG Yan;LIU Zhaoping;SUI Haixia;ZHANG Lei(National Health Commission Key Laboratory of Food Safety Risk Assessment,China National Center for Food Safety Risk Assessment,Beijing 100022,China)
出处
《中国食品卫生杂志》
CSCD
北大核心
2020年第2期190-195,共6页
Chinese Journal of Food Hygiene
基金
国家重点研发计划(2018YFC1603104)
广东省重点领域研发计划(2019B020210002)
北京市自然科学基金项目(7144234)。
