细胞间粘附分子-1水平与2型糖尿病肾病病变程度的关系被引量：4

Relationship between the level of intercellular adhesion molecule-1 and the degree of lesions of type 2 diabetic nephropathy

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摘要目的探讨血清中细胞间粘附分子-1(Intercellular adhesion molecule-1,ICAM-1)的水平与2型糖尿病肾病(Diabetic nephropathy,DN)病变程度的关系。方法选择2017年4月~2019年1月在我院住院2型糖尿病及健康体检者共265例分为五组[对照组、非DN组、早期DN组、临床期DN组(肾功能正常)、临床期DN组(肾功能异常)],观察各组ICAM-1与UAER的关系。结果1.DN各组ICAM-1明显增高,且随着DN病情的加重,ICAM-1水平逐渐升高(对照组:48.00±13.10 ng/mL;非DN组:203.02±30.55 ng/mL;早期DN组:400.32±55.78 ng/mL;临床期DN组(肾功能正常):601.12±51.81 ng/mL;临床期DN组(肾功能异常):863.71±36.44 ng/mL)。2.DN各组UAER均与ICAM-1呈正相关(早期DN组:UAER与ICAM-1的相关系数r=0.789,临床期DN组(肾功能正常):UAER与ICAM-1的相关系数r=0.719,临床期DN组(肾功能异常):UAER与ICAM-1的相关系数r=0.510)。结论ICAM-1与DN病变程度相关,可作为反映DN病情严重程度的参考指标,也可作为DN早期筛查的参考指标。 Objective To investigate the relationship between the level of intercellular adhesion molecule-1(ICAM-1)in serum and the degree of lesions of type 2 diabetic nephropathy(DN).Methods A total of 265 hospitalized patients with type 2 diabetes and healthy subjects in our hospital from April 2017 to January 2019 were selected and divided into five groups[control group,non-DN group,early DN group,clinical stage DN group(normal renal function),clinical stage DN group(abnormal renal function)].The relationship between ICAM-1 and UAER in each group was observed.Results 1.ICAM-1 was increased significantly in each group of DN,and the level of ICAM-1 was gradually increased with the worsening of DN disease(control group:48.00±13.10 ng/mL;non-DN group:203.02±30.55 ng/mL;early DN group:400.32±55.78 ng/mL;clinical stage DN group(normal renal function):601.12±51.81 ng/mL;clinical stage DN group(renal dysfunction):863.71±36.44 ng/mL).2.The UAER of each group of DN was positively correlated with ICAM-1(early DN group:the correlation coefficient of UAER and ICAM-1 was r=0.789;clinical stage DN group(normal renal function):correlation coefficient between UAER and ICAM-1 was r=0.719;clinical stage DN group(renal dysfunction):the correlation coefficient between UAER and ICAM-1 was r=0.510).Conclusion ICAM-1 is related to the degree of DN lesions,and can be used as a reference index to reflect the severity of DN disease.It can also be used as a reference index for early screening of DN.

作者朱虹刘铁奇 ZHU Hong;LIU Tieqi(Department of Endocrinology,the Second Hospital of Chaoyang in Liaoning Province,Chaoyang122000,China;Department of Neurosurgery,the Second Hospital of Chaoyang in Liaoning Province,Chaoyang122000,China)

机构地区辽宁省朝阳市第二医院内分泌科辽宁省朝阳市第二医院神经外科

出处《中国现代医生》 2020年第12期22-25,29,共5页 China Modern Doctor

关键词 ICAM-1 2型糖尿病糖尿病肾病尿白蛋白排泄率 ICAM-1 Type 2 diabetes Diabetic nephropathy(DN) Urinary albumin excretion rate

分类号 R587.2 [医药卫生—内分泌]

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1Hua Ai,Hu-Ping Song.Different expression pattern of serum soluble intercellular adhesion molecules-1 and neutrophilic expression of CD18 in patients with diabetic retinopathy[J].International Journal of Ophthalmology(English edition),2012,5(2):202-207. 被引量：5

二级参考文献30

1Leeuwenberg JF;Smeets EF;Neefjes JJ.E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro,1992(04).
2Miyamoto K,Khosrof S,Bursell SE,et al.Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibitionProceedings of the National Academy of Sciences of the United States of America,1999.
3McLeod D S,Lefer D J,Merges C,Lutty G A.Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroidThe American journal of pathology,1995.
4Fasching P,Veitl M,Rohac M,et al.Elevated concentrations of circulating adhesion molecules and their association with microvascular complications in insulin-dependent diabetes mellitus. Journal of Clinical Endocrinology and Metabolism . 1996
5Joussen AM,Murata T,Tsujikawa A,et al.Leukocyte-mediated endothelial cell injury and death in the diabetic retina. American Journal of Pathology . 2001
6Joussen AM,Poulaki V,Le ML,et al.A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB Journal,The . 2004
7Antonetti DA,Barber AJ,Bronson SK,Freeman WM,Gardner TW,Jefferson LS,Kester M,Kimball SR,Krady JK,LaNoue KF,Norbury CC,Quinn PG,Sandirasegarane L,Simpson IA.Diabetic retinopathy:seeing beyond glucose- induced microvascular disease. Diabetes . 2006
8Huping Song,Lili Wang,Yannian Hui.Expression of CD18 on the neutrophils of patients with diabetic retinopathy[J]. Graefe’s Archive for Clinical and Experimental Ophthalmology . 2007 (1)
9M. S. Boulbou,G. N. Koukoulis,E. A. Petinaki,A. Germenis,K. I. Gourgoulianis.Soluble adhesion molecules are not involved in the development of retinopathy in type 2 diabetic patients[J]. Acta Diabetologica . 2004 (3)
10A. Ramachandran,C. Snehalatha,E. Latha,V. Vijay,M. Viswanathan.Rising prevalence of NIDDM in an urban population in India[J]. Diabetologia . 1997 (2)