摘要
心脏是脊椎动物的中心器官,其适当大小及功能在整个生命周期都是至关重要的。由于心肌损伤造成的心肌梗死、心力衰竭等疾病在全世界范围内的发病率和死亡率逐年上升,目前依然没有找到好的治疗方法。已经发现在新生哺乳动物以及低等脊椎动物中存在多种进化保守的心脏再生机制,然而不幸的是,成年哺乳动物的心脏再生能力极其有限。近年来人们对心肌再生的研究越来越多,有证据表明成年哺乳动物可以产生新的心肌细胞。了解心脏再生的能力,并且掌握其中的原理是心血管方向研究的重要目标。本文主要综述了心肌再生相关分子及信号通路,如转录因子GATA4、微小RNA(microRNA)、Hippo信号通路、ERBB2和Notch通路以及一些炎症因子等发挥的调控作用及其机制。
Heart is the central organ of vertebrates,and its proper size and function are crucial in the whole life cycle.The morbidity and mortality of myocardial infarction,heart failure and other diseases caused by myocardial injury are increasing year by year worldwide,and no good treatment has yet been found.A variety of evolutionarily conserved cardiac regeneration mechanisms have been found in neonatal mammals as well as in lower vertebrates.Unfortunately,the cardiac regeneration capacity of adult mammals is extremely limited.In recent years,more and more studies have been conducted on myocardial regeneration.There are evidences that new cardiomyocytes can be generated in adult mammals.Understanding the ability of cardiac regeneration and how it works is an important goal of cardiovascular research.This review mainly discussed the regulatory effects and mechanisms of myocardial regeneration related molecules and signaling pathways,such as transcription factor GATA4,microRNA,Hippo signaling pathway,ERBB2 pathway,Notch pathway and some inflammation factors,etc.
作者
刘维静
李燕
刘俊
王玉瑶
LIU Weijing;LI Yan;LIU Jun;WANG Yuyao(School of Basic Medical Sciences,Shanxi Medical University,Taiyuan 030001,China)
出处
《生命的化学》
CAS
CSCD
2020年第4期593-599,共7页
Chemistry of Life
基金
国家自然科学基金项目(81500364)
山西省重点研发计划项目(201903D321091)。
