摘要
目的探讨联合检测血清中S100b、神经元特异性烯醇化酶(Neuron-specific enolase,NSE)、白细胞介素-2(Interleukin-2,IL-2)对于高血压脑出血(Hypertensive cerebral hemorrhage,HICH)患者术后并发颅内感染的诊断价值。方法选取2016年1月-2018年7月河北北方学院附属第一医院收治的HICH术后颅内感染患者43例为感染组、同期HICH术后未发生颅内感染患者86例作为对照组,统计并分析两组患者术后第1天、第3天、第7天血清S100b、NSE及IL-2水平,并绘制受试者工作特征曲线(ROC)分析三项指标对HICH患者术后颅内感染的诊断价值。结果两组患者术后第1天、第3天、第7天血清S100b、NSE及IL-2水平比较差异有统计学意义(P<0.05),感染组患者上述指标水平呈现显著的升高趋势,且均高于对照组(P<0.05);术后第3天血清S100b、NSE及IL-2水平联合检测诊断HICH患者术后并发颅内感染的灵敏度为96.36%、特异度为88.27%、漏诊率为3.64%、误诊率为11.73%、AUC值为0.920。结论HICH术后并发颅内感染患者早期即出现血清中S100b、NSE及IL-2水平升高,联合检测对于患者早期诊断具有重要价值。
OBJECTIVE To explore the value of combined detection of serum S100 b,neuron-specific enolase(NSE)and interleukin-2(IL-2)in diagnosis in postoperative intracranial infection in patients with hypertensive cerebral hemorrhage(HICH).METHODS From Jan 2016 to Jul 2018,totally 43 HICH patients with postoperative intracranial infection who were treated in First Affiliated Hospital of Hebei North University were assigned as the infection group,meanwhile,86 HICH patients who were not complicated with postoperative intracranial infection were set as the control group.The levels of serum S100 B,NSE and IL-2 of the two groups of patients were statistically analyzed after the treatment for 1,3 and 7 days,and the value of the three indexes in diagnosis of postoperative intracranial infection was analyzed by using the receiver-operating-characteristic(ROC)curve.RESULTS There were significant differences in the levels of serum S100 b,NSE and IL-2 between the two groups of patients after the treatment for 1,3 and 7 days(P<0.05).The levels of above indexes of the infection group were significantly higher than those of the control group(P<0.05).The sensitivity of the combined detection of serum S100 b,NSE and IL-2 was 96.36%in diagnosis of the postoperative intracranial infection in the HICH patients,the specificity 88.27%,the missed diagnosis rate 3.64%,the misdiagnosis rate 11.73%,the AUC value 0.920.CONCLUSION The levels of serum S100 b,NSE and IL-2 of the HICH patients complicated with postoperative intracranial infection are elevated in early stage,and the combined detection of the three indexes has significant value in early diagnosis.
作者
高继英
石代乐
高晓玲
刘腾飞
王丽雯
曹兵
乔建新
刘春江
刘熙鹏
GAO Ji-ying;SHI Dai-le;GAO Xiao-ling;LIU Teng-fei;WANG Li-wen;CAO Bing;QIAO Jian-xin;LIU Chun-jiang;LIU Xi-peng(First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2020年第9期1365-1368,共4页
Chinese Journal of Nosocomiology
基金
河北省卫计委医学科研计划基金资助项目(20170770)。
