摘要
病毒感染性疾病致病率高、传染性强、危害性大,对人类健康乃至社会发展造成很大威胁,因此寻找预防及治疗药物一直是关注的重点。氯喹、羟基氯喹是美国食品药品管理局批准的治疗疟疾、风湿免疫病的常用药,药品的成本低、安全性高。回顾了多项氯喹、羟氯喹抗病毒的药理研究及临床试验,归纳了二者对于人冠状病毒(HCoVs)、人免疫缺陷病毒(HIV)、寨卡病毒、肠道病毒71型(EV-A71)、朊病毒等多类病毒的作用,其具有广谱抗病毒作用,在临床上有较好的应用前景。
Viral infectious disease have the characteristics of high pathogenicity,strong infectivity and great damage,which pose great threats to human health,and even to social development and stability.Therefore,discovering preventive and therapeutic drugs has always been the focus of society.Chloroquine and hydroxychloroquine are common drugs approved by the US Food and Drug Administration for the treatment of malaria and rheumatic immune disease,with low-budget as well as high safety.This review analyzed studies about the antiviral activity of chloroquine and hydroxychloroquine,including laboratory experiments and clinical trials about human coronavirus,HIV,Zika virus,and enterovirus E-7.The effects of many types of viruses suggestted that chloroquine and hydroxychloroquine possess great clinical application potential.
作者
何蔚
常炳程
HE Wei;CHANG Bingcheng(Department of Pharmacy,Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550000,China;Department of Laboratory,Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550000,China)
出处
《药物评价研究》
CAS
2020年第6期1015-1020,共6页
Drug Evaluation Research
