摘要
目的探讨尿清蛋白/尿肌酐(mAlb/Cr)水平检测对早期糖尿病肾病(EDN)的辅助诊断价值。方法2017年1月-2018年12月在本院确诊的EDN患者138例作为EDN组、同期在本院进行体检的健康志愿者50例作为正常对照组。对比2组晨起尿mAlb/Cr比值以及血清EDN诊断相关指标胱抑素C(CysC)、淀粉样蛋白A(AA)、血肌酐(Scr)、尿素氮(BUN)水平的差异。判断各个检测指标的EDN诊断效能并采用Pearson检验评估尿mAlb/Cr比值与CysC、AA的相关关系。结果EDN组患者的尿mAlb/Cr比值显著高于正常对照组,血清中CysC、AA的水平显著高于正常对照组,差异均有统计学意义(P<0.05)。2组研究对象血清中Scr、BUN水平的差异无统计学意义(P>0.05)。尿mAlb/Cr比值诊断EDN的灵敏度、特异度、准确度均高于血清CysC、AA,差异均有统计学意义(P<0.05)。尿mAlb/Cr比值与血清CysC、AA水平存在正相关关系(P<0.05)。结论EDN患者尿mAlb/Cr比值较正常人群异常升高,且其在EDN诊断中的灵敏度、特异度、准确度较高,单一尿mAlb/Cr比值可作为END辅助诊断的可靠指标。
Objective To study the auxiliary diagnostic value of urinary albumin/creatinine(mAlb/Cr)level in the early diabetic nephropathy(EDN).Methods A total of 138 cases of EDN patients in our hospital from January 2017 to December 2018 were chosen as EDN group,50 cases of healthy volunteers in our hospital at the same time were chosen as the control group.The urine mAlb/Cr ratio and levels of serum CysC,AA,Scr and BUN between two groups were compared.The EDN diagnostic efficiency of each test was determined and Pearson test was used to evaluate the correlation between urine mAlb/Cr ratio and CysC,AA.Results Urinary mAlb/Cr ratio in EDN group was significantly higher than that in the control group,serum levels of CysC and AA were significantly higher than those in the control group,with the difference statistically significant(P<0.05).There was no statistical significance on the difference in serum levels of Scr and BUN between two groups(P>0.05).The sensitivity,specificity and accuracy of urine mAlb/Cr ratio in diagnosing EDN were higher than those of serum CysC and AA(P<0.05).There were a positive correlation between urinary mAlb/Cr ratio and serum CysC and AA levels(P<0.05).Conclusion Urine mAlb/Cr ratio of EDN patients is higher than that in normal population,and its sensitivity,specificity and accuracy in the diagnosis of EDN are high.Single urine mAlb/Cr ratio can be used as a reliable index for the diagnosis of END.
作者
陈雪
杨学茹
CHEN Xue;YANG Xue-ru(Clinical Laboratory,Ningxia Hospital of Traditional Chinese Medicine,Yinchuan,Ningxia 750021,China)
出处
《中国卫生检验杂志》
CAS
2020年第12期1488-1490,共3页
Chinese Journal of Health Laboratory Technology
