摘要
目的分析去感热口服液在急性感染性荨麻疹患者治疗中的临床疗效、安全性及对血清嗜酸性粒细胞阳离子蛋白(eosinophil cationic protein,ECP)、总免疫球蛋白E(total immunoglobulin E,tIgE)及分泌型免疫球蛋白E(secretory immunoglobulin,sIgE)因子的影响。方法纳入2019年7月至2019年10月本院门诊接诊的120例急性感染性荨麻疹患者,随机分为对照组及观察组,每组60例。对照组接受常规抗过敏、抗炎治疗,观察组在对照组基础上予以去感热口服液治疗,疗程均为7 d。对比两组中医证候积分、临床疗效、血清ECP、tIgE、sIgE因子及不良反应发生情况。结果治疗前,两组水肿、风团数量及瘙痒证候积分比较差异无统计学意义(P>0.05)。两组治疗后水肿、风团数量及瘙痒证候积分均较治疗前下降,差异有统计学意义(P<0.05)。治疗后观察组水肿、风团数量及瘙痒证候积分均显著低于对照组,差异具有统计学意义(P<0.01)。观察组临床总有效率为96.67%,高于对照组的76.67%,差异有统计学意义(P<0.05)。治疗前,两组血清ECP、tIgE及sIgE水平比较差异无统计学意义(P>0.05);治疗后,两组患者血清ECP、tIgE及sIgE水平均较治疗前降低,差异有统计学意义(P<0.05);治疗后观察组血清ECP、tIgE及sIgE水平均显著低于对照组,差异具有统计学意义(P<0.01)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论去感热口服液可有效减轻急性感染性荨麻疹患者临床症状及变态反应,且不良反应较少,安全性较高,值得借鉴。
Objective To analyze the clinical efficacy and safety of Quganre oral liquid in the treatment of patients with acute infectious urticaria and its effect on serum eosinophil cationic protein(ECP),total immunoglobulin E(tIgE)and secretory immunoglobulin E(sIgE)factor.Methods From July 2019 to October 2019,120 patients with acute infectious urticaria were randomly divided into control group and observation group,60 in each group.The control group received routine anti allergic and anti-inflammatory treatment,and the observation group was treated with Quganre oral liquid on the basis of the control group for 7 days.The traditional Chinese medicine syndrome score,clinical effects,serum ECP,tIgE,sIgE factors and adverse reactions were compared between the two groups.Results Before treatment,there were no significant difference in edema,number of wind masses and score of pruritus syndrome between the two groups(P>0.05).After treatment,the scores of edema,wind mass and pruritus syndrome in the two groups decreased significantly(P<0.05).After treatment,the scores of edema,wind mass and pruritus syndrome in the observation group were significantly lower than those in the control group(P<0.01).The total clinical effective rate of the observation group was 96.67%,higher than of the control group(76.67%),and the difference was significant(P<0.05).Before treatment,there was no significant difference in the levels of serum ECP,tIgE and sIgE between the two groups(P>0.05).After treatment,the levels of serum ECP,tIgE and sIgE in the two groups were significantly lower than before treatment(P<0.05).After treatment,the levels of serum ECP,tIgE and sIgE in the observation group were significantly lower than those in the control group(P<0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Quganre oral liquid can effectively reduce the clinical symptoms and allergic reactions of patients with acute infectious urticaria,with less adverse reactions and high safety,which is worth learning.
作者
丛林
马志跃
周子力
CONG Lin;MA Zhi-yue;ZHOU Zi-li(Department of Dermatology,Sichuan Second Hospital of Traditional Chinese Medicine,Chengdu 610000,Sichuan Province,China)
出处
《世界临床药物》
CAS
2020年第5期358-363,共6页
World Clinical Drug
