摘要
目的探讨二甲双胍与格列吡嗪单药治疗对初诊2型糖尿病患者胰岛素分泌功能的影响。方法选取2018年7月至2019年7月本院收治的64例初诊2型糖尿病患者,随机分为二甲双胍组和格列吡嗪组,每组32例。二甲双胍组患者应用二甲双胍进行治疗,格列吡嗪组患者应用格列吡嗪进行治疗。比较治疗前后两组患者FPG(空腹血糖)、2h PG(餐后2 h血糖)、HbAlc(糖化血红蛋白)、FINS(空腹胰岛素)、PINS 2h(餐后2h胰岛素)指标水平以及不良反应发生情况。结果治疗后,两组患者FPG、2h PG及HbAlc等指标水平较治疗前均下降(P<0.05),但组间比较差异无统计学意义;两组治疗后FINS水平与治疗前比较差异无统计学意义,格列吡嗪组PINS 2h水平明显高于治疗前及同期二甲双胍组(P<0.05)。两组用药不良反应发生率比较差异无统计学意义。结论二甲双胍与格列吡嗪单药均对初诊2型糖尿病患者有理想效果,且安全性较高,并无严重不良反应,但在实际运用中应根据患者实际情况合理选择。
Objective To investigate the effect of metformin and glipizide on insulin secretion in newly diagnosed type 2 diabetic patients.Methods 64 newly diagnosed type 2 diabetic patients were selected from July 2018 to July 2019 and they were randomly divided into metformin group and glipizide group,with 32 cases in each group.Patients in metformin group were treated with metformin,while patients in glipizide group were treated with glipizide.FPG(fasting blood glucose),2 h PG(postprandial 2 h blood glucose),HbAlc(glycosylated hemoglobin),FINS(fasting insulin),PINS 2 h(postprandial 2 h insulin)and adverse reactions were compared before and after treatment.Results After treatment,FPG,2 h PG and HbAlc decreased significantly in the two groups compared with before treatment(P<0.05),but there was no significant difference between the two groups.Compared with before treatment,there was no statistically significant difference in FINS level between two groups after treatment,and the levels of PINS 2 h in the glipizide group were significantly higher than those in the metformin group before and at the same time(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Both metformin and glipizide have ideal effect on newly diagnosed type 2 diabetic patients,and they have high safety and no serious adverse reactions,and they should be reasonably selected according to the actual situation of patients.
作者
曹峰明
赵宋祥
谢爱玲
Cao Fengming;Zhao Songxiang;Xie Ailing(Department of Endocrine,People's Hospital of Lianxi District,Jiujiang City,Jiujiang,Jiangxi,332005,China)
出处
《当代医学》
2020年第22期18-20,共3页
Contemporary Medicine
