摘要
新生儿缺氧性肺动脉高压(hypoxic pulmonary hypertension,HPH)是新生儿重症监护病房常见的危急重症,其主要的病理特征为肺血管痉挛性收缩与晚期发生的肺血管重塑,重塑的肺血管进一步增加肺动脉压力,并使右心肥厚、衰竭,病变难以逆转。研究表明,生存素作为一系列增殖信号通路的关键枢纽,通过参与调节肺血管细胞的凋亡与增殖状态,加速肺血管重塑,导致疾病进展。该文对生存素在新生儿HPH肺血管重塑中的作用机制研究进展进行综述,旨在为研发逆转新生儿HPH肺血管重塑的方法提供新的方向。
Neonatal hypoxic pulmonary hypertension(HPH)is a common critical illness in the neonatal intensive care unit.Its main pathological features are pulmonary vasospasm and late pulmonary vascular remodeling.The remodeled pulmonary vessels consolidate the increased pressure,which usually followed with right ventricular hypertrophy and heart failure,making them difficult to reverse.Studies have shown that survivin,as a vital hub of a series of proliferative signaling pathways,contributes to vascular remodeling and disease progression by regulating the apoptosis and proliferation of pulmonary vascular cells.This article reviews the research progress of the mechanism of survivin in neonatal HPH pulmonary vascular remodeling and aims to provide a new direction for the method of reversing neonatal HPH pulmonary vascular remodeling.
作者
吴典(综述)
李明霞(审校)
Wu Dian;Li Mingxia(Department of Pediatrics,Xinjiang Medical University,Urumqi 830011,China)
出处
《国际儿科学杂志》
2020年第6期407-410,共4页
International Journal of Pediatrics
基金
国家自然科学基金(81760278)。
关键词
生存素
新生儿
缺氧性肺动脉高压
肺血管重塑
Survivin
Neonate
Hypoxic pulmonary hypertension
Pulmonary vascular remodeling
