摘要
目的分析单核细胞与高密度脂蛋白胆固醇比值(MHR)与急性ST段抬高型心肌梗死(STEMI)患者短期预后的关系。方法筛选2018年6月~2019年6月于景德镇市第一人民医院就诊的60例STEMI患者为研究对象,以MHR值0.46为分组线,≤0.46的为低水平组,>0.46为高水平组,各30例。比较两组的临床资料、实验室检查指标、心功能指标等,随访6个月,统计并比较两组的心血管不良事件(MACE)发生率,并应用Logistic进行单因素分析。结果两组患者的性别、年龄、体质量指数(BMI)比较,差异无统计学意义(P>0.05);两组血脂相关指标甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白C(LDL-C)、高密度脂蛋白C(HDL-C)比较,差异无统计学意义(P>0.05);低水平组肌钙蛋白(c TnT)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)低于高水平组,而低水平组左心室射血分数(LVEF)高于高水平组,两组比较差异有统计学意义(P<0.05);高水平组Gensini评分及MACE发生率高于低水平组,差异有统计学意义(P<0.05)。采用Pearson相关分析进行相关性分析,MHR与MACE呈正关系(r=0.215,P=0.011)。结论MHR值与MACE、心功能、Gensini评分密切相关,对STEMI患者短期预后具有一定的预判作用。
Objective To analyze the relationship between the ratio of monocytes to high density lipoprotein cholesterol(MHR)and short-term prognosis of patients with acute ST-segment elevation myocardial infarction(STEMI).Methods Sixty STEMI patients who were treated at the First People's Hospital of Jingdezhen from June 2018 to June 2019 were screened as the research subjects,with MHR value 0.46 as the grouping line.Patients with MHR≤0.46 were included in the low-level group,and patients with MHR>0.46 were included in the high-level group,with 30 cases in each group.The clinical data,laboratory test indexes,and cardiac function indexes between the two groups were compared.The patients were followed up for 6 months,and the incidence of cardiovascular adverse events(MACE)was analyzed and compared between the two groups by using Logistic univariate analysis.Results There were no statistically significant differences in gender,age and body mass index(BMI)between the two groups(P>0.05).The differences in blood lipid-related indicators triglyceride(TG),total cholesterol(TC),low-density lipoprotein C(LDL-C),high-density lipoprotein(HDL-C)were not significant(P>0.05).The troponin(cTnT),left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)in the low-level group were lower than those of the high-level group,while the left ventricular ejection fraction(LVEF)in the low-level group was higher than that of the high level group,with statistically significant difference(P<0.05).The Gensini score and MACE incidence of high-level group were higher than those of the low-level group,and the difference between the two groups was statistically significant(P<0.05).Correlation analysis by Pearson correlation analysis showed that MHR was positively related to MACE(r=0.215,P=0.011).Conclusion MHR value is closely related to MACE,cardiac function and Gensini score.And it has a certain predictive effect on the short-term prognosis of STEMI patients.
作者
鲁谦
徐慧琳
刘志辉
LU Qian;XU Huilin;LIU Zhihui(Department of Cardiology,the First People's Hospital of Jingdezhen City in Jiangxi Province,Jingdezhen333000,China)
出处
《中国现代医生》
2020年第18期19-22,共4页
China Modern Doctor
基金
江西省景德镇市科技计划项目(20191SFZC005)。
