摘要
肝脏糖脂代谢的平衡与稳定对肝脏胰岛素抵抗有重要意义。微小RNAs可通过调节肝脏糖脂代谢,从而调控肝脏胰岛素抵抗。微小RNA-33a、微小RNA-33b、微小RNA-122、微小RNA-34a、微小RNA-148a-3p以及微小RNA-676可促进脂质合成,抑制脂质分解,导致肝脏脂质积累,诱发肝脏胰岛素抵抗。微小RNA-223与微小RNA-30c可促进脂质分解,抑制脂质合成,减少肝脏脂质积累,改善肝脏胰岛素抵抗。致死因子-7、微小RNA-29、微小RNA-423-5p、微小RNA-802以及微小RNA-155可抑制胰岛素信号途径,从而抑制肝脏葡萄糖摄取,促进肝脏糖异生,导致肝脏胰岛素抵抗。微小RNA-26a与微小RNA-451可抑制肝脏糖异生,改善肝脏胰岛素抵抗。该文通过研究微小RNAs调控肝脏糖脂代谢的机制,阐明了微小RNAs调节肝脏胰岛素抵抗的机制,加深了人们对微小RNAs的认识,为2型糖尿病的治疗提供了有价值的线索。
The balance and stability of liver glucose and lipid metabolism are of great significance to liver insulin resistance.MicroRNAs can regulate liver glucose and lipid metabolism,thereby regulating liver insulin resistance.MicroRNA-33a,microRNA-33b,microRNA-122,microRNA-34a,microRNA-148a-3p and microRNA-676 can promote lipid synthesis,inhibit lipid breakdown,cause liver lipid accumulation and induce liver insulin resistance.MicroRNA-223 and microRNA-30c can promote lipid breakdown,inhibit lipid synthesis,reduce liver lipid accumulation,and improve liver insulin resistance.Lethal factor-7,microRNA-29,microRNA-423-5p,microRNA-802 and microRNA-155 can inhibit the insulin signaling pathway,thereby inhibiting liver glucose uptake,promoting liver gluconeogenesis and causing liver insulin resistance.MicroRNA-26a and microRNA-451 can inhibit liver gluconeogenesis and improve liver insulin resistance.In this article,by studying the mechanism of microRNAs regulation of liver glucose and lipid metabolism,the mechanism of microRNAs regulation of liver insulin resistance was elucidated,deepening people’s understanding of microRNAs,and providing valuable clues for the treatment of type 2 diabetes.
作者
魏鸿瞻
钟连超
高炳宏
WEI Hongzhan;ZHONG Lianchao;GAO Binghong(Shanghai University of Sport,Shanghai 200438,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2020年第6期1063-1070,共8页
Chinese Journal of Cell Biology
基金
2019年上海体育学院高水平国际化人才培养项目资助的课题。
