摘要
目的分析消化道出血患者奥美拉唑联合乌司他丁治疗消化道出血的效果及对胃泌素、止血时间的影响。方法选取济宁医学院附属医院2017年1月至2018年12月收治的68例消化道出血患者为研究对象,采用双盲分析法将其分成对照组与治疗组,每组34例。对照组采用奥美拉唑治疗,治疗组采用奥美拉唑联合乌司他丁治疗。比较两组患者的临床疗效、手术相关指标、胃泌素、胰高血糖素、血流动力学。结果治疗组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗组患者止血时间、腹痛消失时间、输血量及住院时间少于对照组(P<0.05)。治疗前,两组胃泌素、胰高血糖素水平比较差异未见统计学意义(P>0.05);治疗后,两组胃泌素、胰高血糖素水平降低,且治疗组低于对照组(P<0.05)。两组患者治疗前中心静脉压、门静脉压、门静脉内径及门静脉血流速度比较差异未见统计学意义(P>0.05);治疗后,两组中心静脉压、门静脉压、门静脉内径及门静脉血流速度降低,且治疗组低于对照组(P<0.05)。结论奥美拉唑联合乌司他丁治疗消化道出血既能明显改善出血症状、保护消化道功能,又能及时止血,提高疗效。
Objective To investigate the effects of omeprazole combined with ulinastatin on gastrointestinal hemorrhage,and its influence on gastrin level and hemostasis time.Methods Sixty-eight patients with gastrointestinal hemorrhage treated in Affiliated Hospital of Jining Medical College from January 2017 to December 2018 were enrolled,and they were divided into two groups by double-blind method,with 34 cases in each group.Patients in the control group received the omeprazole,while patients in the treatment group received the omeprazole combined with ulinastatin.The clinical effects,general index related to surgery,gastrin,glucagon and hemodynamics of the two groups were compared.Results The clinical effects of the treatment group were superior to the control group(P<0.05).The hemostasis time,disappearance time of abdominal pain,blood transfusion and hospital stay of the treatment group were shorter than those of the control group(P<0.05).The gastrin and glucagon levels had no significant difference between groups before treatment(P>0.05);after treatment,the gastrin and glucagon levels decreased in both groups,and they were lower in the treatment group than in the control group(P<0.05).The central venous pressure,portal pressure,portal vein diameter and portal vein blood flow velocity had no significant difference between groups before treatment(P>0.05),which decreased in both groups after treatment(P<0.05);and these indexes were lower in the treatment group than in the control group(P<0.05).Conclusions Omeprazole combined with ulinastatin in the treatment of gastrointestinal hemorrhage can effectively ameliorate the clinical symptoms and protect the gastrointestinal function,which can stop bleeding in time and promote clinical effects.
作者
张红梅
Zhang Hongmei(Department of Gastroenterology,Affiliated Hospital of Jining Medical College,Jining 272029,China)
出处
《中国实用医刊》
2020年第9期107-110,共4页
Chinese Journal of Practical Medicine
关键词
消化道出血
奥美拉唑
乌司他丁
疗效
胃泌素
止血时间
Gastrointestinal hemorrhage
Omeprazole
Ulinastatin
Curative effect
Gastrin
Hemorrhage time
