摘要
目的观察中西医结合治疗新型冠状病毒(SARS-CoV-2)肺炎(以下简称新冠肺炎)及无症状感染者的疗效。方法选取22例新冠肺炎普通型患者,按照随机数字表法分为2组,对照组11例予重组人干扰素α2b注射液联合盐酸阿比多尔片治疗,治疗组11例在对照组治疗基础上加清热抗毒口服液,2组疗程均为10 d。比较2组发热、咳嗽、乏力消失率及肺部CT病变吸收>50%比例、发热持续时间。选取16例SARS-CoV-2无症状感染者,按照随机数字表法分为2组,无症状对照组8例予重组人干扰素α2b注射液联合盐酸阿比多尔片治疗,无症状治疗组8例在无症状对照组治疗基础上加兰香解毒口服液,2组疗程均为7 d。比较2组咽拭子SARS-CoV-2核酸转阴时间、平均住院时间、咽拭子SARS-CoV-2核酸循环阈值(Ct值)。结果新冠肺炎普通型治疗组患者发热、咳嗽、乏力消失率及肺部CT病变吸收>50%比例、发热持续时间较对照组改善,但比较差异均无统计学意义(P>0.05)。SARS-CoV-2无症状治疗组患者核酸转阴时间和平均住院时间较无症状对照组缩短,但比较差异均无统计学意义(P>0.05)。2组SARS-CoV-2无症状感染者ORF1ab基因、N基因Ct值随着治疗时间的延长而升高,但无症状治疗组第1 d与第7 d,无症状对照组第1、7、14 d组内各时间点两两比较差异均无统计学意义(P>0.05)。第1、7 d 2组无症状感染者ORF1ab基因、N基因Ct值比较差异均无统计学意义(P>0.05),第14 d无症状治疗组ORF1ab基因、N基因Ct值均未检出。结论清热抗毒口服液治疗新冠肺炎普通型患者和兰香口服液治疗SARS-CoV-2无症状感染者均有一定的临床疗效。
Objective To observe the effect of integrated traditional Chinese and western medicine in the treatment of patients with novel coronavirus pneumonia(SARS-CoV-2)and asymptomatic infection.Methods 22 common patients with novel coronavirus pneumonia were divided into two groups according to the random number table method.11 cases in the control group were treated by recombinant human interferonα2b injection combined with arbidol tablets hydrochloride.11 cases in the treatment group were treated by Qingre Kang oral liquid on the basis of the control group.The course of treatment was 10 days in both groups.The disappearance rate of fever,cough and fatigue,the proportion of lung CT lesion absorption>50% and the duration of fever were compared between the two groups.16 patients with SARS-CoV-2 and asymptomatic infection were randomly divided into two groups according to the random number table method.8 cases in the asymptomatic control group were treated by recombinant human interferonα2b injection combined with abidol hydrochloride tablets.8 cases in the asymptomatic treatment group were treated by Lanxiang Jiedu oral liquid on the basis of the asymptomatic control group.The course of treatment in both groups was 7 days.The negative time of SARS-CoV-2 acid from throat swabs,average hospitalization time and circulating threshold(Ct value)of SARS-CoV-2 acid in throat swab were compared between the two groups.Results The common novel coronavirus pneumonia treatment group had a significant improvement in the rate of fever,cough,fatigue,lung CT lesion absorption ratio>50% and fever duration compared with the control group,but there was no significant difference(P>0.05).The time of nucleic acid conversion and the average hospitalization time in SARS-CoV-2 asymptomatic treatment group were shorter than those in asymptomatic control group,but the difference was not statistically significant(P>0.05).The Ct values of ORF1ab gene and N gene were increased in the two groups of SARS-CoV-2 asymptomatic infection with the extension of treatment time,however,there was no significant difference between the asymptomatic infection in the treatment group on the 1st day and the 7th day and the asymptomatic control group on the 1st,7th,and 14th day at each time point(P>0.05).There was no significant difference in the Ct values of ORF1ab gene and N gene between the first and seventh days in the two groups(P>0.05).The Ct values of ORF1ab gene and N gene were not detected in the asymptomatic treatment group on the 14th day.Conclusion Qingre Kang oral liquid has certain clinical effect in treating the patients with common novel coronavirus pneumonia,and Lanxiang Jiedu oral liquid also has a certain clinical effect in the treatment of SARS-CoV-2 asymptomatic infection.
作者
王瑜玲
薛剑
戴二黑
许尊贵
冯彩霞
刘洪德
高会霞
赵磊
WANG Yuling;XUE Jian;DAI Erhei(Department of Internal Medicine,The Fifth Hospital of Shijiazhuang City,Hebei 050021;不详)
出处
《河北中医》
2020年第5期645-649,共5页
Hebei Journal of Traditional Chinese Medicine
基金
石家庄市卫生健康委2020年石家庄市科研专项资金项目(编号:201460513A-3)
石家庄市科学技术局新型冠状病毒肺炎防控应急科研攻关项目。
关键词
肺炎
病毒性
冠状病毒感染
中西医结合疗法
Pneumonia,viral
Coronavirus infection
Integrated traditional Chinese and western medicine therapy
