摘要
【目的】探讨同轴微切口超声乳化白内障吸出术对角膜内皮细胞的损伤及修复的影响。【方法】选取2017年1月至2017年12月在本院诊治的423例白内障患者,根据切口大小分为两组,其中标准切口组(3.0 mm)221例,微切口组(1.8~2.2 mm)202例,两组术前、术后1 d、1周、1个月、3个月采用角膜内皮显微镜检查角膜内皮细胞密度、角膜内皮细胞变异系数和形态并比较。【结果】术前,两组患者术眼角膜内皮细胞密度、变异系数、六角形细胞比例、中央角膜厚度比较差异均无统计学意义(P>0.05)。两组术后7 d、术后3个月术眼角膜内皮细胞密度均显著大于术前,角膜内皮细胞变异系数均显著高于术前,六角细胞比例显著低于术前,其差异均有统计学意义(P<0.05)。术后7 d,微切口组术眼角膜内皮细胞密度显著大于标准切口组;微切口组六角细胞比例大于标准切口组,差异有统计学意义(P<0.05);术后3个月,术眼角膜内皮细胞密度、六角细胞差异均无统计学意义(P>0.05)。术后7 d、术后3个月角膜内皮细胞变异系数、中央角膜厚度比较差异均无统计学意义(P>0.05)。【结论】同轴微切口超声乳化白内障吸出术对角膜内皮细胞的损伤较常规切口小,术后恢复快,值得临床推广应用。
【Objective】To investigate the effect of coaxial micro incision phacoemulsification on corneal endothelial cell injury and repair.【Methods】A total of 423 cataract patients who were treated in our hospital from January 2017 to December 2017 were selected and divided into two groups according to the size of incision,including 221 cases in standard incision group(3.0 mm)and 202 cases in micro incision group(1.8-2.2 mm);corneal endothelial cell density,coefficient of variation and morphology of corneal endothelial cells were examined by corneal endothelial microscope and compared before operation,1 day,1 week,1 month and 3 months after operation.【Results】Before operation,there were no significant differences in corneal endothelial cell density,coefficient of variation,proportion of hexagonal cells and central corneal thickness between the two groups(P>0.05).The corneal endothelial cell density at 7 days and 3 months after operation in the two groups were significantly higher than that before operation,the variation coefficient of corneal endothelial cells was significantly higher than that before operation,and the proportion of hexagonal cells was significantly lower than that before operation(P<0.05).At 7 days after operation,the density of corneal endothelial cells in the micro incision group was significantly higher than that in the standard incision group;the proportion of hexagonal cells in the micro incision group was higher than that in the standard incision group,and the difference was statistically significant(P<0.05);at 3 months after operation,there was no statistical significance in the corneal endothelial cell density and hexagonal cell(P>0.05).There was no significant difference in the coefficient of variation of corneal endothelial cells and central corneal thickness at 7 days and 3 months after operation(P>0.05).【Conclusion】Compared with conventional incision,coaxial micro incision phacoemulsification has less damage to corneal endothelial cells and faster postoperative recovery,which is worthy of clinical application.
作者
张晓城
陈茂盛
贺翔鸽
吴平
文燕
ZHANG Xiao-cheng;CHEN Mao-sheng;HE Xiang-ge(Chongqing beibei aer ophthalmic hospital,Chongqing 400700)
出处
《医学临床研究》
CAS
2020年第7期1061-1063,共3页
Journal of Clinical Research
