摘要
比较宫颈癌近距离治疗中肿块体积在50~90 cm^3之间,应用3D打印阴道模型塞插植治疗与常规三维腔内治疗的剂量学差异,研究3D打印阴道模型塞应用在大肿块宫颈癌近距离治疗中的可行性,为临床应用提供参考。收集甘肃省肿瘤医院放疗科2017年5月至2019年5月收治的宫颈癌患者行近距离放射治疗,肿块体积在50~90 cm^3之间的患者27例,其中14例患者在近距离治疗中行3D打印阴道模型塞插植治疗(3D printing interstitial BT,3DP-ISBT),另13例行常规三维腔内治疗(Intracavitary BT,ICBT)。在高危临床靶区(HR-CTV)处方剂量为6 Gy的情况下,评估HR-CTV体积大小,HR-CTV的D90(90%体积接收到的最低吸收剂量)、膀胱、直肠的剂量学差异。与ICBT组相比,3DP-ISBT组HR-CTV的体积及D90、直肠大于1 cm^3、2 cm^3、3 cm^3体积接收到的吸收剂量D1cc、D2cc和D3cc均无统计学差异(p>0.05)。膀胱的D1cc、D2cc和D3cc低于ICBT组,有统计学差异(p<0.05)。宫颈癌近距离治疗中肿块体积在50~90 cm3之间应用3DP-ISBT技术在剂量学上能够满足临床要求,与ICBT技术相比能更好地保护膀胱,在直肠的保护上未显示出优势。
In this study,we aimed to determine the dosimetric differences between 3D-printing multi-channel applicator interstitial brachytherapy(3DP-ISBT)and conventional three-dimensional intracavity treatment(ICBT)for cervical cancer with a high-risk clinical target volume(HR-CTV)of 50~90 cm3,to determine the feasibility of using 3DP-ISBT,and to provide a basis for the application of 3DP-ISBT in clinical practice.The study included 27 patients with cervical cancer and an HR-CTV of 50~90 cm3 who underwent radiotherapy at Gansu Provincial Cancer Hospital between May 2017 and May 2019.Among them,14 patients were treated with 3DP-ISBT and 13 were treated with ICBT.With a prescription dose was 6 Gy,evaluated the volume of the HR-CTV,the dosimetric differences in D90(received absorbed dose of 90%of the HR-CTV)of the HR-CTV,bladder,and rectum.Compared with the ICBT group,the 3DP-ISBT group showed no statistical differences in volume of the HR-CTV,D90 of the HR-CTV,and D1cc,D2cc,and D3cc of the rectum(doses received by 1 cm^3,2 cm^3,and 3 cm3 of the rectal volume)(p>0.05).D1cc,D2cc,and D3cc of the bladder were lower in the 3DP-ISBT group than in the ICBT group,and the difference was statistically significant(p<0.05).3DP-ISBT for cervical cancer with an HR-CTV volume of 50~90 cm3 can meet clinical requirements.The target can be irradiated with a sufficient dose in large-volume cancer and can protect the bladder better than can ICBT,however,there are no advantages in terms of protection of the rectum.
作者
陶娜
安永伟
欧阳水根
罗莉
孙晓燕
张春林
魏玺仪
TAO Na;AN Yongwei;OUYANG Shuigen;LUO Li;SUN Xiaoyan;ZHANG Chunlin;WEI Xiyi(Department of Radiotherapy,Gansu Provincial Cancer Hospital,Lanzhou 730050,China)
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
2020年第4期51-56,共6页
Journal of Radiation Research and Radiation Processing
关键词
宫颈癌
3D打印阴道模型塞
腔内治疗
剂量学
Cervical cancer
3D printing multi-channel applicator
Intracavity treatment
Dosimetry
