摘要
目的:探讨CO2点阵激光联合曲安奈德注射液封包治疗稳定期白癜风的临床疗效及安全性。方法:按照随机数字法将2018年1月-2019年5月笔者医院收治的240例稳定期白癜风患者分为A、B、C、D组,每组60例。A组(脉冲能量30mJ,点阵覆盖率6.3%)与B组(脉冲能量100mJ,点阵覆盖率1.2%)均采用CO2点阵激光联合曲安奈德注射液封包进行治疗,C组(脉冲能量100mJ,点阵覆盖率1.2%)与D组(脉冲能量30mJ,点阵覆盖率6.3%)采用CO2点阵激光进行治疗,连续治疗6个月。治疗后随访6个月,比较四组的临床疗效、复发率及不良反应;比较治疗后即刻、1个月、3个月四组的患者生活质量评分和满意度评分。结果:A组的总有效率(95.00%vs76.67%,55.00%,80.00%)明显高于B、C、D组(P<0.05),B组与D组明显高于C组(P<0.05)。治疗后1个月、3个月,A组、B组、D组的生活质量评分与满意度评分较治疗后即刻均无明显变化(P>0.05),C组在治疗后3个月的生活质量评分与满意度评分均明显降低(P<0.05);各时间点A组的生活质量评分与满意度评分均明显高于B组、C组、D组(P<0.05),B组与D组明显高于C组(P<0.05)。A组、B组、D组的复发率(1.67%,5.00%,5.00%vs20.00%)明显低于C组(P<0.05),四组之间的不良反应发生率比较,差异无统计学意义(P>0.05)。结论:低能量高密度CO2点阵激光联合曲安奈德注射液封包治疗稳定期白癜风疗效好、安全性高,可以作为白癜风的较佳临床治疗方案。
Objective To investigate the clinical efficacy and safety of CO2 lattice laser combined with triamcinolone acetonide injection packet in the treatment of vitiligo in stable phase.Methods According to the random number method,240 patients with vitiligo in stable phase who were divided into group A,group B,group C and group D in our hospital from January 2018 to May 2019,with 60 patients in each group.The patients were treated by CO2 lattice laser combined with triamcinolone acetonide injection packet in group A(pulse energy 30 mJ,lattice coverage rate 6.3%)and group B(pulse energy 100 mJ,lattice coverage rate 1.2%).The patients were treated by CO2 lattice laser in group C(pulse energy 100 mJ,lattice coverage rate 1.2%)and group D(pulse energy 30 mJ,lattice coverage rate 6.3%).All patients were continuously treated for 6 months.The patients were followed up for 6 months after treatment,and the clinical efficacy,recurrence rate and adverse reactions of the 4 groups were compared.The quality of life scores and satisfaction scores of the 4 groups were compared immediately,1 month and 3 months safter treatment.Results The total effective rate(95.00%vs 76.67%,55.00%,80.00%)in group A was significantly higher than that in group B,group C and group D(P<0.05),the group B and group D was significantly higher than that in group C(P<0.05).The scores of life quality and satisfaction in group A,group B and group D at 1 and 3 months after treatment showed no significant changes compared with those immediately after treatment(P>0.05),the scores of life quality and satisfaction in group C were significantly reduced 3 months after treatment(P<0.05).The scores of life quality and satisfaction in group A was significantly higher than that in group B,group C and group D(P<0.05),the group B and group D was significantly higher than that in group C(P<0.05).The recurrence rate(1.67%,5.00%,5.00%vs 20.00%)in group A,group B and group D was significantly lower than that in group C(P<0.05).There was no significant difference on incidence of adverse reactions between 4 groups(P>0.05).Conclusion Low energy and high density of CO2 lattice laser combined with triamcinolone acetonide injection packet had a good efficacy and high safety in the treatment of vitiligo in stable phase.It could be used as a better clinical treatment plan for vitiligo.
作者
张玲
张绚辉
张杨梅
谭晓智
曾海燕
陈廷婷
刘品梅
杨万英
刘超
ZHANG Ling;ZHANG Xuan-hui;ZHANG Yang-mei;TAN Xiao-zhi;ZENG Hai-yan;CHEN Ting-ting;LIU Pin-mei;YANG Wan-ying;LIU Chao(Department of Dermatology,Affi liated Longhua People’s Hospital,Southern Medical University(Longhua People’s Hospital),Shenzhen 518109,Guangdong,China;Tanluo Social Health Center,Affi liated Longhua People’s Hospital,Southern Medical University(Longhua People’s Hospital),Shenzhen 518109,Guangdong,China)
出处
《中国美容医学》
CAS
2020年第8期62-65,共4页
Chinese Journal of Aesthetic Medicine
基金
深圳市龙华区2018年科技创新专项资金(编号:2017091)。
关键词
白癜风
CO2点阵激光
曲安奈德
光电治疗
临床疗效
vitiligo
CO2 lattice laser
triamcinolone acetonide
phototherapy
clinical efficacy
