摘要
目的探讨初乳口腔免疫预防早产儿呼吸机相关性肺炎(VAP)的效果。方法选择2017年3月至2018年2月该院儿科NICU行经口气管插管机械通气早产儿58例,分为试验组(初乳口腔免疫)和对照组(生理盐水口腔免疫)。比较两组早产儿机械通气时VAP发生率、口腔感染发生率、机械通气时间和口腔分泌物细菌培养情况。结果试验组VAP发生率和口腔感染发生率显著小于对照组,差异有统计学意义(P<0.05);其中试验组3例VAP早产儿气管导管内痰培养为革兰阴性菌,口腔分泌物细菌培养没有检出相同细菌;对照组11例VAP早产儿导管内痰培养与口腔分泌物细菌培养有7例检出相同细菌;两组早产儿机械通气时间比较差异无统计学意义(P>0.05)。结论初乳口腔免疫能有效预防早产儿VAP的发生。
Objective To investigate the effect of colostrum oral immune therapy on prevention of ventilator-associated pneumonia(VAP)in premature infants.Methods Fifty-eight cases of mechanically ventilated preterm infants from NICU from March 2017 to February 2018 were randomly divided into two groups:the experimental group(colostrum for oral immune)and the control group(normal saline for oral immune).The incidence of VAP,mechanical ventilation time,incidence of oral infection,bacterial culture of oral secretions and endotracheal tube sputum were compared between the two groups of preterm infants.Results The occurrence of VAP and oral infection in the experimental group was significantly lower than that in the control group,the differences were statistically significant(P<0.05).3 cases of VAP in the experimental group were cultured as Gram-negative bacteria in the endotracheal tube,and the same bacteria were not detected in the oral culture,while in the control group,7 cases were found to have the same bacteria in endotracheal sputum culture and oral secretion bacteria culture.The mechanical ventilation time between the two groups of premature infants was not statistically significant(P>0.05).Conclusion Colostrum oral immunization can effectively reduce the incidence of VAP in premature infants.
作者
何丽
肖静
温恩懿
HE Li;XIAO Jing;WEN Enyi(Department of Pediatrics,the Second Affiliated Hospital of Army Medical University,Chongqing 400037,China)
出处
《重庆医学》
CAS
2020年第16期2751-2754,共4页
Chongqing medicine
基金
重庆市社会事业与民生保障科技创新专项(cstc2017shmsA130013)。
关键词
初乳
婴儿
早产
口腔免疫
通气机
机械
肺炎
呼吸机相关性
colostrum
infants
premature
oral immune therapy
ventilators
mechanical
pneumonia
ventilator-associated
