摘要
回顾针灸对呼吸系统和全身免疫炎性反应调控的影响,探讨神经免疫调控对控制炎性反应的可能作用途径以及通过胆碱能抗炎通路治疗新型冠状病毒肺炎(简称"新冠肺炎")的作用途径。针灸可能通过激活胆碱能抗炎通路等途径对新冠肺炎发挥局部和全身抗炎效应。与体液抗炎通路相比,神经抗炎通路启动早、作用迅速、更局限化,在炎性反应的初始关键阶段起着更重要的作用,这可能是新冠肺炎早期进行针灸干预的重要依据。除了胆碱能抗炎通路,针灸还可能通过激活交感神经、下丘脑-垂体-肾上腺轴等神经抗炎通路发挥抗炎效应。针灸在炎性反应的不同时期如何通过躯体刺激激活迷走和交感神经等通路来发挥作用,是否依赖于穴位的选择、刺激的方式等,这将是针灸基础向临床转化研究的方向。
The effect of acupuncture-moxibustion on respiratory system and systemic immune inflammatory response were reviewed to explore the possible role of neuroimmunomodulation in the control of inflammatory response and the effect mechanism of cholinergic anti-inflammatory pathway on coronavirus disease 2019(COVID-19).Acupuncture-moxibustion could produce the local and systemic anti-inflammatory effect on COVID-19 through the activation of cholinergic anti-inflammatory pathway.Compared with humoral anti-inflammatory pathway,the neuronal anti-inflammatory pathway has earlier initiation,rapider action,and more localization,which play a more important role in the initial stage of inflammatory response.This may be an important basis for acupuncture-moxibustion intervention in the early stage of COVID-19.In addition to cholinergic anti-inflammatory pathway,acupuncture-moxibustion may also play an anti-inflammatory role in activating sympathetic nerve,hypothalamic-pituitary-adrenal axis and other neural anti-inflammatory pathways.How acupuncture-moxibustion play its role in stimulating the vagus nerve and sympathetic nerve in different periods of inflammatory response,and whether the effect is based on the selection of acupoints and the methods of stimulation,will be the research direction of the transformation from basic research to clinical research for acupuncture-moxibustion.
作者
何伟
石啸双
张知云
宿杨帅
万红叶
王毅
喻晓春
朱兵
景向红
HE Wei;SHI Xiao-shuang;ZHANG Zhi-yun;SU Yang-shuai;WAN Hong-ye;WANG Yi;YU Xiao-chun;ZHU Bing;JING Xiang-hong(Institute of Acupunture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China;China Association of Acupunture-Moxibustion)
出处
《中国针灸》
CAS
CSCD
北大核心
2020年第8期799-802,809,共5页
Chinese Acupuncture & Moxibustion
基金
国家重点研发计划资助项目:2019YFC1709002
国家自然科学基金资助项目:81973964。
关键词
新型冠状病毒肺炎
针灸
炎性反应
神经免疫调节
coronavirus disease 2019(COVID-19)
acupuncture and moxibustion
inflammatory response
neuroimmune regulation
