摘要
前庭疾病可引起眩晕、头晕、前庭-视觉症状和姿势症状等,严重影响患者工作效力及自身安全。目前,抗组胺药物是用于对抗前庭症状的主要治疗药物。其中,倍他司汀为代表的以H1和H3受体为靶点的抗组胺药物,已经在临床使用了几十年。文中通过回顾文献,详细阐述了组胺及中枢组胺受体的生理作用、前庭疾病与中枢组胺受体的相互关系、倍他司汀的药理作用机制和临床应用,以期为相关临床用药提供参考。
Vestibular disorders,which cause vestibular symptoms(such as vertigo,dizziness,vestibular-visual symptoms and postural symptoms,etc.),may seriously affect patients’work productivity and their safety.At present,antihistamine drugs are the most used drugs for the treatment of vestibular symptoms.Among them,drugs that target H1 and H3 receptors represented by betahistine have been used clinically for decades.Based on literature review,the physiological functions of histamine and central histamine receptors,the relationship between vestibular diseases and central histamine receptors,and the pharmacological mechanism and clinical application of betahistine are elaborated in order to provide reference for clinical medication.
作者
庄建华
ZHUANG Jian-hua(Department of Neurology.the Second Affiliated Hospital of Naval Military Medical University,200003 Shanghai,China)
出处
《中国临床神经科学》
2020年第3期287-300,共14页
Chinese Journal of Clinical Neurosciences
关键词
组胺
中枢神经系统
组胺受体
前庭疾病
倍他司汀
histamine
central nervous system
histamine receptor
vestibular disorders
betahistine
