摘要
目的探讨二甲双胍联合门冬胰岛素30注射液强化治疗新发2型糖尿病患者的临床效果。方法选取2016年8月~2019年1月我院收治的156例新发2型糖尿病患者,按照随机数字表法分为对照组(78例)与观察组(78例)。两组均给予二甲双胍,在此基础上,对照组给予精蛋白生物合成人胰岛素注射液治疗,观察组给予门冬胰岛素30注射液强化治疗,比较两组的临床疗效、血糖水平、血糖达标时间、动态血糖监测指标、生活质量评分。结果观察组的临床总有效率(97.44%)高于对照组(87.18%),差异有统计学意义(P<0.05)。观察组的血糖达标时间短于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的空腹血糖、餐后2 h血糖水平均低于对照组,差异有统计学意义(P<0.05)。观察组的高血糖时间比、低血糖时间比、血糖波动系数、低血糖发生率均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论二甲双胍联合门冬胰岛素30注射液强化治疗,可更好地控制新发2型糖尿病患者的血糖水平,尽快降低血糖,还可减少血糖波动,降低低血糖的发生率,有利于提高生活质量。
Objective To investigate the clinical effect of Metformin combined with Insulin Aspart 30 Injection in the treatment of newly developed type 2 diabetes mellitus.Methods A total of 156 cases of patients with newly developed type 2 diabetes who admitted to our hospital from August 2016 to January 2019 were selected,they were divided into control group(78 cases)and observation group(78 cases)according to the random number table method.Metformin was given to both groups,on this basis,the control group was given Isophane Protamine Biosynthetic Human Insulin Injection treatment,and the observation group was given Insulin Aspart 30 Injection intensive treatment.The clinical efficacy and blood sugar level,time of blood sugar reaching the standard,dynamic blood sugar monitoring index and quality of life score were compared between the two groups.Results The total clinical effective rate(97.44%)of the observation group was higher than that of the control group(87.18%),the difference was statistically significant(P<0.05).The time of blood glucose reaching the standard in the observation group was shorter than that in the control group,the difference was statistically significant(P<0.05).After treatment,the levels of fasting blood glucose and 2 h postprandial blood glucose in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The time ratio of hyperglycemia,time ratio of hypoglycemia,fluctuation coefficient of blood glucose and incidence of hypoglycemia in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the quality of life score in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion Metformin combined with Insulin Aspart 30 Injection intensive therapy can better control the blood sugar level of patients with newly developed type 2 diabetes mellitus,reduce the blood sugar level as soon as possible,reduce the fluctuation of blood sugar,reduce the incidence of hypoglycemia,and improve the quality of life.
作者
韦珍红
WEI Zhen-hong(Department of Endocrinology,Laibin People′s Hospital,Guangxi Zhuang Autonomous Region,Laibin546100,China)
出处
《中国当代医药》
2020年第23期78-81,共4页
China Modern Medicine
