摘要
高毒力肺炎克雷伯菌具有高毒力、高黏性的特点,能引起肺炎、菌血症、肝脓肿、脑膜炎等疾病,严重者还会危及生命。目前,高毒力肺炎克雷伯菌致病机制的研究显示,铁载体毒力基因在其中发挥着重要作用。与高毒力肺炎克雷伯菌毒力密切相关的铁载体主要包括气杆菌素、肠杆菌素、耶尔森菌素和沙门菌素。铁载体相关毒力基因主要包括aer、iucB、iroNB和kfuBC。该文着眼于高毒力肺炎克雷伯菌致病机制中铁载体毒力基因的作用简要综述,旨在指导感染防控。
Hypervirulent Klebsiella pneumoniae has the characteristics of high virulence and high viscosity, which can cause pneumonia, bacteremia, liver abscess, meningitis and other diseases, and in severe cases, it can be lifethreatening. At present, studies on the pathogenic mechanism of hypervirulent Klebsiella pneumoniae showed that siderophore virulence genes play an important role in it. The siderophores closely related to hypervirulent Klebsiella pneumoniae virulence mainly include aerobactin, enterobactin, yersiniabactin and salmochelin. Siderophore-related virulence genes mainly include aer, iucB, iroNB and kfuBC. This article focuses on a brief review of the role of siderophore virulence genes in the pathogenic mechanism of hypervirulent Klebsiella pneumoniae, and aims to guide infection control.
作者
韩睿辉
杜艳
HAN Ruihui;DU Yan(Department of Clinical Laboratory,the First Affiliated Hospital of Kunming Medical University/Yunnan Key Laboratory of Laboratory Medicine/Yunnan Institute of Laboratory Diagnosis,Kunming,Yunnan 650032,P.R.China)
出处
《华西医学》
CAS
2020年第8期991-994,共4页
West China Medical Journal
基金
国家自然科学基金(81960382)。
关键词
高毒力肺炎克雷伯菌
毒力基因
铁载体
Hypervirulent Klebsiella pneumoniae
Virulence genes
Siderophore
