摘要
背景:由于中枢神经系统的固有再生能力有限,脊髓损伤常导致患者出现永久性的感觉、运动及自主神经功能障碍,严重影响其生活质量,目前临床上尚无有效改善神经功能恢复的方法。现研究认为间充质干细胞分泌组由于介导了细胞移植的主要治疗作用且避免了细胞排异等问题,因此将成为治疗脊髓损伤的有力工具。目的:总结间充质干细胞分泌组治疗脊髓损伤的研究进展,并分析目前面临的问题及其未来发展方向。方法:以“spinal cord injury,secretome”为关键词检索PubMed数据库,以“脊髓损伤,分泌组”为关键词检索CNKI、万方数据库,检索时限为2013年1月至2020年1月,排除与文章研究目的无关及重复性文章,纳入符合标准的71篇文献进行综述。结果与结论:间充质干细胞分泌组中富含各种生长因子、神经营养因子等可溶性分子及细胞外囊泡,在减少细胞凋亡、调节免疫应答、抑制瘢痕形成、促进神经再生及血管形成方面都起到了显著作用。大量的研究表明,间充质干细胞分泌组可以促进脊髓损伤后的神经再生及功能恢复,且避免了细胞移植的种种弊端,未来将成为治疗脊髓损伤的可靠方法。
BACKGROUND:Spinal cord injury often leads to patients’permanent sensory,motor and autonomic dysfunction because of limited inherent regeneration capacity of the central nervous system.Spinal cord injury seriously affects patients’quality of life but there is still no effective treatment for it.The existing studies suggest that mesenchymal stem cell secretome mediates the main therapeutic effect of cell transplantation and avoids problems such as cellular rejection,so it will become a powerful tool for the treatment of spinal cord injury.OBJECTIVE:To summarize the research progress of mesenchymal stem cell secretome in the treatment of spinal cord injury,and analyze the current problems and future development direction.METHODS:The PubMed database was retrieved with“spinal cord injury,secretome”as the keywords,and Chinese databases include CNKI and Wanfang were retrieved with“spinal cord injury,secretome”as the keywords in Chinese.We retrieved the articles published from January 2013 to January 2020 and excluded the articles that were irrelevant or repetitive.At last 71 articles that met the criteria were included for review.RESULTS AND CONCLUSION:The mesenchymal stem cell secretome is rich in extracellular vesicles and soluble molecules such as growth factors and neurotrophic factors,and it plays prominent place in reducing cell apoptosis,regulating immune response,inhibiting scar formation,promoting nerve regeneration and angiogenesis.Numerous studies have shown that the mesenchymal stem cell secretome can promote nerve regeneration and function recovery after spinal cord injury,and it avoids the disadvantages of cell transplantation.The mesenchymal stem cell secretome will become a reliable method to treat spinal cord injury in the future.
作者
万然
史旭
刘京松
王岩松
Wan Ran;Shi Xu;Liu Jingsong;Wang Yansong(Department of Orthopedics,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2021年第7期1088-1095,共8页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金面上项目(81871781),项目负责人:王岩松。
关键词
脊髓损伤
间充质干细胞分泌组
神经再生
无细胞治疗
综述
spinal cord injury
mesenchymal stem cell secretome
nerve regeneration
cell-free treatment
review
