摘要
目的:探讨对小儿肺炎支原体脑炎联合使用丙种球蛋白和糖皮质激素治疗的临床效果和安全性。方法:将本院于2017年9月—2019年10月收治的60例肺炎支原体脑炎的患儿作为研究对象,采用随机抽签的方式分组,其中30例纳入常规组,单纯使用糖皮质激素治疗,其余30例纳入治疗组,联合使用丙种球蛋白和糖皮质激素治疗,比较两组治疗效果。结果:治疗组和常规组总有效率分别是93.33%(28/30)和76.67%(23/30),组间对比存在明显差异(P<0.05);治疗组退热的时间为(2.66±1.01)d、X线片显示阴影的消失时间为(3.96±0.99)d、惊厥症状得到控制的时间为(1.67±0.95)d、意识恢复的时间为(13.14±2.21)h、住院时长为(6.11±2.22)d,各项数据均短于对照组,组间对比存在明显差异(P<0.05)。结论:对小儿肺炎支原体脑炎联合使用丙种球蛋白和糖皮质激素治疗可以明显缩短症状消失的时间,促进尽早康复,节约治疗成本,提高临床治疗效果,临床应用价值显著。
Objective:To study the efficacy and safety of glucocorticoid plus gamma globulin in mycoplasma pneumoniae encephalitis children.Methods:60 mycoplasma pneumoniae encephalitis children treated from September 2017 to October 2019 in our hospital were selected and assigned to two groups according to lottery method,30 cases in each group.The conventional group just took glucocorticoid;treatment group took gamma globulin and glucocorticoid.Therapeutic effects were probed.Results:The overall response rate in the treatment group(93.33%,28/30)was significantly higher than conventional group(76.67%,23/30)(P<0.05);the time of fever abatement,X-ray imaging disappearance,convulsion relief,consciousness recovery and hospital stays in the treatment group was(2.66±1.01)d,(3.96±0.99)d,(1.67±0.95)d,(13.14±2.21)h and(6.11±2.22)d,which were significantly shorter than control group(P<0.05).Conclusion:Gamma globulin combined with glucocorticoid can significantly shorten the symptom relief time,promote the fast recovery,save the treatment costs and improve the therapeutic effects.
作者
李华梅
王群
曾燕玲
尤建良
Li Huamei;Wang Qun;Zeng Yanling;You Jianliang(Department Of Neurology,Quanzhou Women’s And Children’s Hospital,Fujian Province,362000)
出处
《北方药学》
2020年第7期169-170,共2页
Journal of North Pharmacy
关键词
肺炎
支原体脑炎
儿童
糖皮质激素
丙种球蛋白
治疗效果
安全性
Pneumoni
Mycoplasma pneumoniae encephalitis
Children
Glucocorticoid
Gamma globulin
Therapeutic effect
Safety
