摘要
目的探讨慢性乙型肝炎(CHB)患者甲状腺功能的变化及临床意义。方法选取2016年1月至2019年12月我院收治的300例CHB作为研究组,另选取同期至我院健康体检者268例为对照组。比较两组T3、T4、TSH、FT3和FT4的差异。根据病情严重程度,将CHB患者分为轻度组126例,中度组102例,重度组72例,比较各组T3、T4、TSH、FT3和FT4的差异,分别分析T3、T4、TSH、FT3、FT4与血清白蛋白、总胆红素和凝血酶原时间(PT)的相关性。结果研究组T3、T4、FT3和FT4均明显低于对照组,且差异均有统计学意义(P<0.05),而两组间TSH无明显差异。慢性乙型肝炎重度组T3、T4、FT3和FT4均低于轻度组和中度组,且差异均有统计学意义(P<0.05)。在CHB患者中,T3、T4、FT3和FT4分别与血清白蛋白呈正相关,与总胆红素、PT呈负相关(P<0.05),而TSH与血清白蛋白、总胆红素、PT均无明显相关性(P>0.05)。结论 CHB患者T3、T4、FT3和FT4水平降低,并且与病情严重程度密切相关。
Objective To investigate the changes of thyroid function in patients with chronic hepatitis B(CHB) and its clinical significance.Methods From Jan.2016 to Dec.2019,300 cases of CHB admitted to our hospital were selected as the study group,and 268 cases of healthy people who came to our hospital for physical examination in the same period were selected as the control group.The differences of T3,T4,TSH,FT3 and FT4 were compared between these two groups.According to the severity of the disease,CHB patients were divided into three groups:the mild group(n=126),the moderate group(n=102) and the severe group(n=72).The differences of T3,T4,TSH,FT3 and FT4 were compared among these three groups.We also analyzed the correlation of T3,T4,TSH,FT3,FT4with serum albumin,total bilirubin and prothrombin time(PT),respectively.Results Compared with those in the control group,patients in the study group had lower levels of T3,T4,FT3 and FT4(P<0.05).There was no significant difference in TSH between the two groups(P>0.05).Patients in the severe group had lower levels of T3,T4,FT3 and FT4 than those in the mild and moderate groups(P<0.05).In patients with CHB,T3,T4,FT3 and FT4 were positively correlated with serum albumin while negatively correlated with total bilirubin and PT(P<0.05).TSH had no significant correlation with serum albumin,total bilirubin and PT(P>0.05).Conclusion The levels of T3,T4,FT3 and FT4are lower in patients with CHB and closely related to the severity of the disease.
作者
王林芳
WANG Lin-fang(Jiaxing First Hospital,Jiaxing 314000,China)
出处
《中国地方病防治》
CAS
2020年第4期473-475,共3页
Chinese Journal of Control of Endemic Diseases
关键词
慢性乙型肝炎
甲状腺功能
临床意义
Chronic hepatitis B
Thyroid function
Clinical significance
