摘要
骨组织工程的发展对支架材料提出了更高要求。基于再生医学的完全再生理论,要求骨移植替代物具备骨诱导性的同时,还能被破骨细胞降解并替换为新生骨组织。可吸收支架材料能被破骨细胞降解,且材料的理化性质也影响着破骨细胞的行为。其中材料表面微结构是启动骨诱导性的关键,对破骨细胞行为具有重要影响。此外,材料表面粗糙度在一定范围内可增强破骨细胞的功能活性。就材料表面微结构对破骨细胞调控作用的研究进展作一综述,以进一步探讨其作用机制,为制备性能更佳的组织工程支架材料提供参考。
The development of bone tissue engineering puts forward higher requirements for scaffold materials.Based on the theory of complete regeneration in regenerative medicine,bone graft substitutes are required to be osteoinducible,and to be degraded by osteoclasts and replaced with new bone tissue.Absorbable scaffold materials can be degraded by osteoclasts,and their physical and chemical properties also affect the behavior of osteoclasts.The surface microstructure of the materials is the key to initiating osteoinduction,and it has an important influence on the behavior of osteoclasts.In addition,the surface roughness of the materials can enhance the functional activity of osteoclasts within a certain range.In this paper,the research progress in material surface microstructure regulating osteoclastic cells were reviewed,in order to further explore its mechanism of action,and provide a reference for the preparation of better performance tissue engineering scaffold materials.
作者
谭艳林
张强
刘秀飘
熊博凯
杨佩佩
杨羽晨
Tan Yanlin;Zhang Qiang;Liu Xiupiao;Xiong Bokai;Yang Peipei;Yang Yuchen(Department of Oral and Maxillofacial Surgery,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China)
出处
《国际生物医学工程杂志》
CAS
2020年第3期244-249,共6页
International Journal of Biomedical Engineering
基金
国家自然科学基金(81560189)
江西省卫计委课题(20155348)
江西省研究生创新专项资金项目(YC2017-S086)。
关键词
组织支架
生物相容性材料
破骨细胞
表面微结构
Tissue scaffolds
Biocompatible materials
Osteoclasts
Surface microstructure
