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基于“肺阳虚-痰瘀互结”探索儿童哮喘的发病机制 被引量:17

Exploration of the pathogenesis of childhood asthma based on"lung Yang deficiency-Phlegm Blood Stasis"
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摘要 中医理论认为儿童哮喘以痰瘀为夙根,与肺脾肾三脏不足密切相关。而痰瘀为有形阴邪,必因阳不化气、水停血滞而成,认为儿童哮喘应有脏腑阳气虚损的病理基础;加之小儿属“稚阴稚阳”之体,处于以阳气为主导的生长发育阶段,易受外邪、饮食因素影响,造成阳气亏耗;或因先天禀赋不足,生而阳气本虚。肺是哮喘的直接核心病位,阳气虚者在于肺也,认为肺阳虚是儿童哮喘发病的基本病机,也是痰瘀形成的重要原因。随着病程延长,病理产物逐渐产生、积聚,终致痰瘀胶结,形成“肺阳亏虚-气血津液失常-痰瘀伏肺”的动态病机演变过程,三者互为因果贯穿于儿童哮喘始终,是其反复发作、缠绵难愈的重要原因。 The theory of traditional Chinese medicine believes that children's asthma takes phlegm and blood stasis as the root,which is closely related to the deficiency of lung,spleen and kidney.Phlegm and blood stasis are Yin pathogen,which must be caused by Yang failing to transform Qi and stagnation of water,stasis of blood.It is believed that children’s asthma should have a pathological basis of viscera and Yang deficiency.In addition,children's constitution is“childish Yin and Yang”,they are susceptible to take external and dietary evils,resulting in a situation of Yang depletion;or due to innate insufficiency,borned with deficiency of Yang Qi.The lung is the direct core location of asthma,the deficiency of Yang is in the lung.It is believed that deficiency of Yang of lung is the basic pathogenesis of asthma in children.As the course of the disease prolongs,pathological products gradually produce and accumulate,eventually resulting in phlegm and blood stasis cementation,forming a dynamic pathogenesis of"deficiency of lung Yang-imbalance of Qi,blood and body fluid-phlegm and blood stasis in lung",the three factors are the cause and effect of each other throughout childhood asthma,which is an important reason for repeated attack and lingering of childhood asthma.
作者 陈迪 李建保 王霞 徐婧 李蓝轩 CHEN Di;LI Jian-bao;WANG Xia;XU Jing;LI Lan-xuan(Hospital of Traditional Chinese Medicine of Xinjin,Sichuan,Xinjin 611430,China;Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;The first people's Hospital of Suining,Sichuan,Suining 629000,China)
出处 《中国中医基础医学杂志》 CAS CSCD 北大核心 2020年第8期1068-1069,1113,共3页 JOURNAL OF BASIC CHINESE MEDICINE
基金 国家自然科学基金资助项目(81574027)-基于“虚-痰-瘀”夙根理论对支气管哮喘气道重塑中诱导纤维异常修复的HMGB1调控机制研究。
关键词 肺阳虚 痰瘀互结 儿童哮喘 Deficiency of lung Yang Phlegm and Blood stasis Childhood asthma
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