摘要
目的:对肝功能正常的HBeAg阴性慢性乙型肝炎(CHB)患者的肝组织病理结果与临床指标进行分析与研究。方法:将2018年2月-2019年2月到我院接受治疗的41例肝功能正常的HBeAg阴性CHB患者选取为研究对象,对患者采取肝功能、HBsAg及HBV DNA检测,并对患者的肝组织病理结果进行分析。结果:在41例肝功能正常的HBeAg阴性CHB患者中,年龄与血清HBsAg呈负相关关系(P<0.05);肝组织炎症与肝纤维化分期呈显著正相关关系(P<0.01)。按照炎症分级分组比较:炎症程度<G2与炎症程度≥G2比较,随着HBV DNA水平的上升,肝组织炎症有加重的趋势;组间年龄、血清HBsAg、HBV DNA差异无统计学意义(均P>0.05);按照纤维化分期分组比较:纤维化分期<S2与纤维化分期≥S2比较,组间年龄、血清HBsAg、HBV DNA差异无统计学意义(均P>0.05)。结论:对肝功能正常的HBeAg阴性CHB患者需及早进行肝组织穿刺活检术明确肝脏炎症及纤维化情况,进一步评估病情明确治疗方案,对防治CHB的疾病进展有着十分重要的意义。
Objective:To analyze and study the liver histopathological results and clinical indicators of HBeAgnegative chronic hepatitis B(CHB)patients with normal liver function.Methods:41 HBeAg-negative CHB patients with normal liver function who were treated in our hospital from February 2018 to February 2019 were selected as the research objects.The patients were tested for liver function,HBsAg and HBV DNA,and the patients’liver Histopathological results were analyzed.Results:Among 41 HBeAg-negative CHB patients with normal liver function,age was negatively correlated with serum HBsAg(P<0.05);liver tissue inflammation was significantly positively correlated with liver fibrosis stages(P<0.01).Grouping comparison according to inflammation grade:Compared with inflammation degree<G2 and inflammation degree≥G2,with the increase of HBV DNA level,liver tissue inflammation tended to aggravate;there was no significant difference in age,serum HBsAg,HBV DNA between groups(P>0.05);Group comparison according to fibrosis stage:Compared with fibrosis stage<S2 and fibrosis stage≥S2,there was no significant difference in age,serum HBsAg,HBV DNA between groups(P>0.05).Conclusion:For HBeAg-negative CHB patients with normal liver function,it is necessary to perform liver biopsy as soon as possible to confirm liver inflammation and fibrosis,further evaluate the condition and clarify the treatment plan,which is of great significance for the prevention and treatment of CHB disease progression.
作者
张先姚
张国梁
侯勇
施美
李梦梦
王姣
ZHANG Xianyao;ZHANG Guoliang;LI Mengmeng;WANG Jiao(Anhui University of Chinese Medicine,Anhui Hefei 230000,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230000,China)
出处
《中医药临床杂志》
2020年第8期1491-1493,共3页
Clinical Journal of Traditional Chinese Medicine
基金
国家自然基金项目(81874451)。
