摘要
目的:探讨饮酒对不育男性精液质量的影响。方法:499例行精液常规及精子形态检查不育男性患者,按是否饮酒分为不育饮酒组(n=269)及不育非饮酒组(n=230),同期已生育的394例正常男性作为正常生育组(饮酒量<20 g/d),不育饮酒组按乙醇含量分为低(<20 g/d,n=91)、中(20~90 g/d,n=95)及高酒量组(>90 g/d,n=83);所有受检者禁欲3~7 d,手淫方式收集精液,比较各组受检者精液量与液化时间;取各组受检者液化后精液0.05 mL,采用beions3全自动精子质量分析系统检测精子总数、前向运动精子、精子浓度及精子活力;采用精子染色液对精子染色后,观察精子形态、计算精子正常形态率。结果:不育非饮酒组和不育饮酒组受检者的精子总数、精子浓度、向前运动精子、精子活力及正常形态率分别低于正常生育组(P<0.05),不育饮酒组前向运动精子、精子活力、正常形态率低于不育非饮酒组(P<0.05);高、中酒量组受检者的精子浓度、向前运动精子、精子活力及正常形态率低于不育非饮酒组(P<0.05),低酒量组受检者的向前运动精子、精子活力及正常形态率低于不育非饮酒组(P<0.05),中酒量组受检者的精子浓度、向前运动精子、精子活力及正常形态率高于高酒量组(P<0.05),低酒量组向前运动精子、精子活力及正常形态率分别高于中、高酒量组(P<0.05)。结论:饮酒导致男性精液质量降低,可能是导致男性生育力下降甚至不育的重要原因之一。
Objective:To investigate the effect of alcohol drinking on the semen quality of infertile Guiyang male.Methods:499 infertile male patients underwent routine semen and sperm morphology check were divided into infertile drinking group(n=269)and infertile non-drinking group(n=230).394 health man(with children)were chosen as the normal fertility group(drinking amount<20 g/d).In terms of alcohol consumption,the infertile drinking group was further divided into low alcohol consumption group(<20 g/d,n=91),medium alcohol consumption group(20-90 g/d,n=95)and high drinking group(>90 g/d,n=83).All subjects abstained from sex for 3 to 7 days.Semen were collected by masturbation,and compared semen volume and liquefaction time between each group.0.05 mL liquefied semen from each group were analyzed:using beions3 automatic sperm quality analysis system to detect the total number of sperm,forward motility sperm,sperm concentration and sperm motility.At the same time,sperms were stained with sperm staining solution,and its morphology were observed and calculated the normal morphological rate of sperm.Results:The total number of sperm,sperm concentration,forward-moving sperm,sperm motility,and normal morphological rate of subjects in the infertile non-drinking group and infertile drinking group were lower than those of the normal fertility group(P<0.05).The forward-moving sperm,sperm motility,and normal morphology rate of sperm from sterile drinking group was lower than that of infertile non-drinking group(P<0.05);the sperm concentration,forward-moving sperm,sperm motility,and normal morphology rate of the high and medium alcohol groups were lower than that in the non-drinking group(P<0.05);the forward-moving sperm,sperm motility,and normal morphological rate of low-alcohol group were lower than that of infertile non-drinking group(P<0.05).The sperm concentration,forward-moving sperm,sperm motility and normal morphology rate of medium alcohol group was higher than that of high-alcoholic group(P<0.05).The forward-moving sperm,sperm motility and normal morphology rate in low-alcoholic group was higher than that of medium and high-alcoholic group(P<0.05).Conclusion:Drinking alcohol leads to decreased quality in male semen,which may be one of the important reasons for the decline of male fertility,and even contributed to infertility.
作者
申雪慧子
吴宁
陈朝军
陈红
谭宗建
SHEN Xuehuizi;WU Ning;CHEN Chaojun;CHEN Hong;TAN Zongjian(Reproductive Center,Guizhou Provincial People's Hospital,Guiyang 550002,Guizhou,China;School of Basic Medical Science,Guizhou Medical University,Guiyang 550004,Guizhou,China)
出处
《贵州医科大学学报》
CAS
2020年第9期1067-1071,共5页
Journal of Guizhou Medical University
基金
贵州省科学技术厅科技计划项目[黔科合LH字(2014)7035]。
关键词
不育
饮酒
精液分析
精子
贵阳市
男性
infertility
alcohol drinking
semen analysis
spermatozoa
guiyang city
male
