摘要
目的对在体检人群中应用定量CT(QCT)技术测量肝脏脂肪含量的可重复性进行评估,为QCT应用于临床肝脏脂肪含量测量提供依据。方法2019年4-7月,连续抽取在河南省人民医院健康管理科行QCT检查的291例体检者,男性214例(73.5%),女性77例(26.5%),年龄(48.7±11.0)岁。采用QCT工作站测量体检者的肝脏脂肪含量,由3位测量者(A、B、C)在QCT工作站上独立测量肝脏脂肪含量,测量者A在2周后重复测量1次,测量者A两次测量结果取均值作为其最终测量结果。采用均数±标准差描述计量资料,采用组内相关系数(ICC)评价测量者间和测量者内测量结果的可重复性。结果测量者A的第1次测量结果为(10.46±5.55)%,第2次为(10.66±5.59)%,最终结果为(10.56±5.51)%;测量者B、C测量结果分别为(10.70±5.45)%、(10.86±5.77)%。测量者A、B、C之间肝脏脂肪测量结果的ICC=0.960(95%CI:0.951~0.967,P<0.001)。测量者A的2次肝脏脂肪测量结果ICC=0.953(95%CI:0.941~0.962,P<0.001)。均ICC>0.75,一致性均较好。结论在测量方法一致的前提下,采用QCT工作站测得的肝脏脂肪含量结果在测量者间和测量者内都具有良好的重复性,有一定的临床应用前景。
Objective To provide support for the clinical application of quantitative computed tomography(QCT)in the measurement of liver fat content,this study evaluated the intra-observer and inter-observer reproducibility of liver fat content measured by QCT in a population receiving physical examinations.Methods From April to July 2019,291 people were consecutively selected who underwent QCT examination in the health management department of Henan Provincial People′s Hospital.There were 214 males(73.5%)and 77 females(26.5%),aged 48.7±11.0.We measured liver fat content by QCT workstation.Three observers(A,B,C)measured their liver fat content independently,then observer A performed re-testing two weeks later.The mean value of the two measurements from observer A was taken as the final result.Measurement data were described by mean±SD.Intra-observer and inter-observer reproducibility were assessed using intra-class correlation coefficients(ICC).Results The first measurement result for observer A was 10.46±5.55 and the second measurement for observer A was 10.66±5.59,resulting in a final value of 10.56±5.51.The measurement results of observers B and C were 10.70±5.45 and 10.86±5.77,respectively.The ICC value of liver fat content values measured by the three observers was 0.960(95%CI:0.951-0.967,P<0.001)and the ICC value of liver fat content values for the two measurements of observer A was 0.953(95%CI:0.941-0.962,P<0.001).The ICC values were>0.75,so reproducibility of results was good.Conclusions If the measurement method is consistent,the results for liver fat content measured by a conventional CT scanner and QCT workstation will have good reproducibility between and within observers,and will also have certain clinical application prospects.
作者
陈白如
郭鸣周
屈敏
张潇琳
马会民
赵小娟
邹智
李永丽
Chen Bairu;Guo Mingzhou;Qu Min;Zhang Xiaolin;Ma Huimin;Zhao Xiaojuan;Zou Zhi;Li Yongli(Zhengzhou University People′s Hospital,Department of Radiology of Henan Provincial People′s Hospital,Zhengzhou 450003,China;Department of Medical Equipment of Henan Provincial People′s Hospital,Zhengzhou University People′s Hospital,Zhengzhou 450003,China;Department of Health Management of Henan Provincial People′s Hospital,Zhengzhou University People′s Hospital,Zhengzhou 450003,China;Department of Radiology of Henan Provincial People′s Hospital,Zhengzhou University People′s Hospital,Zhengzhou 450003,China)
出处
《中华健康管理学杂志》
CAS
CSCD
2020年第4期318-321,共4页
Chinese Journal of Health Management
基金
国家重点研发计划资助(2017YFB1002502)
河南省科技厅科技攻关项目(172102310115)
科技厅省科学自然基金(162300410285)。
关键词
定量CT
脂肪肝
结果可重复性
Quantitative computed tomography
Liver fat
Reproducibility of results
