摘要
近年来,上皮-间质转化(EMT)在恶性肿瘤中的作用得到重视,而信号通路如TGF-β、Wnt、Notch以及Hedgehog(Hh)、黏蛋白(MUC)、微小核糖核酸(miRNA)、转录因子和生长因子等均参与了EMT形成过程。本研究将结合以上信号通路及相关因子介质对EMT在各系统恶性肿瘤发病和侵袭转移中的作用做简要综述。
Recent years,the role of epithelial-mesenchymal transition(EMT)in malignant tumors has been valued.The related signaling pathways such as TGF-β、Wnt、Notch and Hedgehog(Hh),mucin(MUC),microRNA(miRNA),transcription factors,growth factors and so on,have been involved in the course of EMT.This paper will briefly review the role of EMT in the pathogenesis and invasion of various malignant tumors from the above signaling pathways and related factor media.
作者
潘琦璐
马礼兵
PAN Qilu;MA Libing(Department of Respiratory and Critical Care Medicine,Affiliated Hospital of Guilin Medical University,Institute of Respiratory Diseases,Guilin Medical University,Key Laboratory of Respiratory Diseases of Colleges and Universities Affiliated Education Department of Guangxi Zhuang Autonomous Region,Guilin 541001,China)
出处
《实用医学杂志》
CAS
北大核心
2020年第17期2443-2447,共5页
The Journal of Practical Medicine
基金
国家自然科学基金(编号:81760009,81560007)
广西自然科学基金(编号:2015GXNSFAA139106)。
关键词
上皮间质转化
信号通路
恶性肿瘤
epithelial-mesenchymal transition
signaling pathways
malignant tumors
